Scully B E, Henry S A
Rev Infect Dis. 1985 Nov-Dec;7 Suppl 4:S789-93. doi: 10.1093/clinids/7.supplement_4.s789.
Aztreonam was used for the treatment of gram-negative bacteremia in 101 patients. In 34 instances a second antibiotic was prescribed for the treatment of suspected or documented gram-positive or anaerobic infection. The sources of bacteremia were the urinary tract (50 patients), an intraabdominal site (17), the respiratory tract (8), an intravascular site (9), and an unknown site (17). The clinical response rate was 92% (91 of 99 patients). The bacteriologic response rate was 97% (98 of 101 patients). In six of seven patients, Pseudomonas aeruginosa bacteremia was cured. Twelve patients developed superinfection with gram-positive cocci or Candida, and one patient developed diarrhea associated with Clostridium difficile. No other serious toxic effects were noted.
氨曲南用于治疗101例革兰阴性菌血症患者。在34例病例中，还开具了第二种抗生素用于治疗疑似或确诊的革兰阳性菌或厌氧菌感染。菌血症的来源为尿路（50例患者）、腹腔内部位（17例）、呼吸道（8例）、血管内部位（9例）和不明部位（17例）。临床有效率为92%（99例患者中的91例）。细菌学有效率为97%（101例患者中的98例）。7例患者中有6例铜绿假单胞菌菌血症得到治愈。12例患者发生革兰阳性球菌或念珠菌二重感染，1例患者出现艰难梭菌相关性腹泻。未观察到其他严重毒性作用。
