回旋加速器生产锰-52：多模态PET/MRI成像的一条有前景的途径。

Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging.

作者信息

Porto Francesca, Cisternino Sara, Cazzola Emiliano, Speltri Giorgia, Mou Liliana, Boschi Alessandra, Marvelli Lorenza, Di Domenico Giovanni, Pagnoni Antonella, De Dominicis Lucia, Calliari Irene, Gennari Claudio, Uccelli Licia, Pupillo Gaia, Gorgoni Giancarlo, Esposito Juan, Martini Petra

机构信息

Department of Translational Medicine, University of Ferrara, Via Fossato di Mortara, 70 c/o viale Eliporto, 44121, Ferrara, Italy.

Legnaro National Laboratories (LNL-INFN), National Institute for Nuclear Physics, Viale dell'Università, 2, 35020, Legnaro, PD, Italy.

出版信息

EJNMMI Radiopharm Chem. 2024 Aug 2;9(1):57. doi: 10.1186/s41181-024-00288-6.

DOI:10.1186/s41181-024-00288-6

PMID:39093479

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11297007/

Abstract

BACKGROUND

The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of Mn for PET/MRI imaging.

RESULTS

Using the Cr(p,n)Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.

CONCLUSIONS

The developed technology offers a promising avenue for producing Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.

摘要

背景

正电子发射断层扫描（PET）与磁共振成像（MRI）的融合有望提升诊断成像能力。METRICS项目旨在开发用于PET/MRI成像的回旋加速器驱动的锰生产方法。

结果

利用Cr(p,n)Mn反应，我们通过放电等离子烧结设计了铬金属靶，并开发了一种分离程序以分离锰。使用传统螯合剂（即S-2-(4-异硫氰酸苄基)-1,4,7,10-四氮杂环十二烷四乙酸）和1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-碳二硫代酸酯配体进行标记测试，以制备适用于PET/MRI应用的放射性配合物。我们的方法产生了适用于PET放射性药物和PET/MRI成像的高质量锰。使用微型PET和临床MRI对体模成像进行的初步研究证明了我们方法的有效性。