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Breaking up Mucus Plugs in Asthma.

作者信息

Busse William W, Jarjour Nizar N

机构信息

Division of Allergy, Pulmonary and Critical Care Medicine University of Wisconsin School of Medicine and Public Health Madison, Wisconsin.

出版信息

Am J Respir Crit Care Med. 2024 Dec 15;210(12):1389-1390. doi: 10.1164/rccm.202406-1244ED.

DOI:10.1164/rccm.202406-1244ED
PMID:39093594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11716041/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c07/11716041/419ff3ba0661/rccm.202406-1244EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c07/11716041/419ff3ba0661/rccm.202406-1244EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c07/11716041/419ff3ba0661/rccm.202406-1244EDf1.jpg

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Am J Respir Crit Care Med. 2024 Dec 15;210(12):1389-1390. doi: 10.1164/rccm.202406-1244ED.
2
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Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence.哮喘黏液栓的细胞和分子特征为其形成和持续存在提供了线索。
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本文引用的文献

1
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.严重哮喘中Muc5AC增加和纤毛细胞减少通过抑制IL-4Rα受体得到部分恢复。
Am J Respir Crit Care Med. 2024 Dec 15;210(12):1409-1420. doi: 10.1164/rccm.202307-1266OC.
2
Emerging cell and molecular targets for treating mucus hypersecretion in asthma.治疗哮喘黏液高分泌的新兴细胞和分子靶点。
Allergol Int. 2024 Jul;73(3):375-381. doi: 10.1016/j.alit.2024.04.002. Epub 2024 May 1.
3
Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals.
嗜酸粒细胞-黏液相互作用在严重哮喘中的作用：对生物制剂治疗的影响。
Allergol Int. 2024 Jul;73(3):351-361. doi: 10.1016/j.alit.2024.03.001. Epub 2024 Mar 13.
4
Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.特泽布尔单抗联合黏液栓在中重度哮喘患者中的应用
NEJM Evid. 2023 Oct;2(10):EVIDoa2300135. doi: 10.1056/EVIDoa2300135. Epub 2023 Sep 20.
5
Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial.度普利尤单抗对中重度哮喘患者黏液阻塞和通气缺陷的影响：一项随机、双盲、安慰剂对照试验。
Am J Respir Crit Care Med. 2023 Nov 1;208(9):995-997. doi: 10.1164/rccm.202306-1102LE.
6
Successful treatment with dupilumab for mucus plugs in severe asthma.度普利尤单抗成功治疗重度哮喘中的黏液栓。
Respirol Case Rep. 2022 Dec 15;11(1):e01074. doi: 10.1002/rcr2.1074. eCollection 2023 Jan.
7
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.黏液栓在哮喘中持续存在，并且随时间推移黏液栓的变化与气流变化相关。
Am J Respir Crit Care Med. 2022 May 1;205(9):1036-1045. doi: 10.1164/rccm.202110-2265OC.
8
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.哮喘患者的黏液栓与嗜酸性粒细胞增多和气流阻塞有关。
J Clin Invest. 2018 Mar 1;128(3):997-1009. doi: 10.1172/JCI95693. Epub 2018 Feb 5.
9
The role of mucus in fatal asthma.黏液在致死性哮喘中的作用。
Am J Med. 2003 Jul;115(1):68-9. doi: 10.1016/s0002-9343(03)00260-2.
10
The presence or absence of bronchial mucus in fatal asthma.
J Allergy Clin Immunol. 1987 Sep;80(3 Pt 2):415-6. doi: 10.1016/0091-6749(87)90064-9.