Polymeric and Soft Materials Laboratory, Advanced Institute of Materials Science, School of Chemical Engineering, Changchun University of Technology, Changchun, Jilin 130012, China.
Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
ACS Appl Mater Interfaces. 2024 Aug 14;16(32):41949-41959. doi: 10.1021/acsami.4c09902. Epub 2024 Aug 2.
Management of diabetic chronic wound exudate is a serious challenge in healthcare worldwide since it is related to the speed of diabetic wound healing. However, current foam dressings not only absorb fluid to generate swelling and compress the wound to hinder wound healing but also are very thick and less comfortable to use. Herein, a superabsorbent self-pumping ultrathin dressing is reported to accelerate diabetic wound healing by achieving superior exudate absorption and management in an ultrathin state. The self-pumping dressing is composed of a drainage layer loaded with anthocyanidin and a thermoplastic polyurethane absorbent layer embedded with superabsorbent particles. The dressing realizes the self-pumping process of unidirectional exudate draining to the absorption layer through the drainage layer without significant dressing swelling to compress the diabetic wound. The dressing is experimentally proven to unidirectionally drain excessive exudate with inflammatory factors and modulate the conversion of macrophages from M1 to M2 in diabetic wounds, thereby promoting the healing of diabetic skin ulcers faster than commercial foam dressings. Therefore, the dressing provides a new idea and novel method for accelerating diabetic skin ulcer healing.
糖尿病慢性伤口渗出物的管理是全球医疗保健的一个严峻挑战，因为它与糖尿病伤口愈合的速度有关。然而，目前的泡沫敷料不仅吸收液体以产生肿胀并压缩伤口以阻碍伤口愈合，而且非常厚，使用起来不太舒适。在此，报告了一种超吸水性自吸超薄敷料，通过在超薄状态下实现优异的渗出物吸收和管理来加速糖尿病伤口愈合。自吸敷料由负载有花色苷的引流层和嵌入有超吸水性颗粒的热塑性聚氨酯吸收层组成。该敷料通过引流层实现了单向渗出物引流到吸收层的自吸过程，而不会使敷料显著肿胀以压缩糖尿病伤口。该敷料经实验证明可单向排出过多的具有炎症因子的渗出物，并调节糖尿病伤口中巨噬细胞从 M1 向 M2 的转化，从而比商业泡沫敷料更快地促进糖尿病皮肤溃疡的愈合。因此，该敷料为加速糖尿病皮肤溃疡愈合提供了新的思路和新颖的方法。
