Department of Food and Nutrition, College of Natural Science and Public Health and Safety, Chosun University, Gwangju, Republic of Korea.
Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju, Republic of Korea.
Medicine (Baltimore). 2024 Aug 2;103(31):e38769. doi: 10.1097/MD.0000000000038769.
This study aimed to investigate the association between high-sensitivity C-reactive protein (hs-CRP) levels, as a surrogate marker of systemic inflammation, and renal function among Korean adults grouped by age, sex, and body mass index. This study analyzed data obtained from the Korea National Health and Nutrition Examination Survey 2015 to 2018, a cross-sectional and nationally representative survey conducted by the Korean Centers for Disease Control and Prevention. Of the 22,451 subjects included in this study, 19,607 (87.3%) and 2844 (12.7%) had normal kidney function and incident chronic kidney disease, respectively. Reduced renal function was more frequently observed in subjects with high hs-CRP levels than in those with low hs-CRP levels (odds ratio [OR], 1.438; 95% confidence interval [CI], 1.234-1.674). In the group aged ≥ 65 years, the odds of reduced renal function were higher among subjects with a high hs-CRP level compared to those with a low hs-CRP level (OR, 1.528; 95% CI, 1.191-1.960). The association between hs-CRP level and renal function was observed only in women (OR, 2.485; 95% CI, 1.779-3.470) and further stratified by age and sex, the odds of reduced renal function were likely higher in women aged ≥ 65 years with a high hs-CRP level (OR, 2.338; 95% CI, 1.622-3.369). Moreover, reduced renal function was more observed in subjects aged ≥ 65 years and those with a body mass index < 25 kg/m2 (OR, 1.502; 95% CI, 1.087-2.075). This study showed that a high hs-CRP level likely contributes to the increased prevalence of reduced renal function. This association may aid the identification of individuals at high risk for reduced renal function, especially elderly women, in clinical or public health practice.
本研究旨在探讨高敏 C 反应蛋白（hs-CRP）水平作为全身炎症的替代标志物与韩国成年人按年龄、性别和体重指数分组的肾功能之间的关联。本研究分析了 2015 年至 2018 年由韩国疾病控制与预防中心进行的全国代表性横断面调查——韩国国家健康和营养检查调查的数据。在本研究纳入的 22451 名受试者中，分别有 19607（87.3%）和 2844 人（12.7%）肾功能正常和发生慢性肾病。hs-CRP 水平较高的受试者中，肾功能降低的比例高于 hs-CRP 水平较低的受试者（比值比 [OR]，1.438；95%置信区间 [CI]，1.234-1.674）。在年龄≥65 岁的人群中，与 hs-CRP 水平较低的受试者相比，hs-CRP 水平较高的受试者肾功能降低的几率更高（OR，1.528；95%CI，1.191-1.960）。hs-CRP 水平与肾功能之间的关联仅在女性中观察到（OR，2.485；95%CI，1.779-3.470），进一步按年龄和性别分层后，hs-CRP 水平较高的年龄≥65 岁女性肾功能降低的几率更高（OR，2.338；95%CI，1.622-3.369）。此外，在年龄≥65 岁和体重指数<25kg/m2 的受试者中，肾功能降低更为常见（OR，1.502；95%CI，1.087-2.075）。本研究表明，hs-CRP 水平升高可能导致肾功能降低的患病率增加。这种关联可能有助于在临床或公共卫生实践中识别肾功能降低风险较高的个体，尤其是老年女性。
