[Transplantation of allogeneic bone marrow treated in vitro with Campath-1 monoclonal antibody].
作者信息
Chapuis B, Helg C, Maurice P, Wyss M, Pipard G, Irlé C, Jeannet M
出版信息
Schweiz Med Wochenschr. 1985 Oct 26;115(43):1521-2.
PMID:3909387
Abstract
5 patients underwent bone marrow transplantation for severe aplastic anemia (2) and acute leukemia (ALL) in first remission (3). Graft versus host disease prophylaxis was performed by depleting T lymphocytes in the donor bone marrow with the rat monoclonal Campath-1 and autologous complement. In addition, patients received cyclosporin A. Engraftment occurred normally in all 5 patients but 1 patient (SAA) had a late graft failure. Two patients suffered mild degrees of GvHD. All patients are currently in complete remission, one having undergone a second transplantation.
摘要
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