Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Nyírő Gyula Hospital, Laboratory for Perception & Cognition and Clinical Neuroscience, Budapest, Hungary.
Cephalalgia. 2024 Jul;44(7):3331024241258722. doi: 10.1177/03331024241258722.
Altered sensory processing in migraine has been demonstrated by several studies in unimodal, and especially visual, tasks. While there is some limited evidence hinting at potential alterations in multisensory processing among migraine sufferers, this aspect remains relatively unexplored. This study investigated the interictal cognitive performance of migraine patients without aura compared to matched controls, focusing on associative learning, recall, and transfer abilities through the Sound-Face Test, an audiovisual test based on the principles of the Rutgers Acquired Equivalence Test.
The performance of 42 volunteering migraine patients was compared to the data of 42 matched controls, selected from a database of healthy volunteers who had taken the test earlier. The study aimed to compare the groups' performance in learning, recall, and the ability to transfer learned associations.
Migraine patients demonstrated significantly superior associative learning as compared to controls, requiring fewer trials, and making fewer errors during the acquisition phase. However, no significant differences were observed in retrieval error ratios, generalization error ratios, or reaction times between migraine patients and controls in later stages of the test.
The results of our study support those of previous investigations, which concluded that multisensory processing exhibits a unique pattern in migraine. The specific finding that associative audiovisual pair learning is more effective in adult migraine patients than in matched controls is unexpected. If the phenomenon is not an artifact, it may be assumed to be a combined result of the hypersensitivity present in migraine and the sensory threshold-lowering effect of multisensory integration.
多项单模态，尤其是视觉任务的研究表明偏头痛存在感觉处理改变。虽然有一些有限的证据表明偏头痛患者的多感觉处理可能存在改变，但这方面仍未得到充分探索。本研究通过基于鲁特格斯获得性等价测试原理的视听测试 Sound-Face Test，调查了无先兆偏头痛患者的发作间期认知表现，与匹配的对照组进行比较，重点关注联想学习、回忆和转移能力。
将 42 名志愿偏头痛患者的表现与 42 名匹配对照者的数据进行比较，这些对照者是从先前接受过测试的健康志愿者数据库中选择的。该研究旨在比较两组在学习、回忆和转移已习得联想的能力方面的表现。
与对照组相比，偏头痛患者的联想学习能力明显更好，在获得阶段需要更少的试验次数，并且错误更少。然而，在测试的后期阶段，偏头痛患者和对照组之间在检索错误率、泛化错误率或反应时间方面没有观察到显著差异。
我们的研究结果支持先前的研究结论，即多感觉处理在偏头痛中表现出独特的模式。联想视听配对学习在成年偏头痛患者中比在匹配对照组中更有效的特定发现是出乎意料的。如果这种现象不是人为的，那么可以假设它是偏头痛中存在的超敏性和多感觉整合的感觉阈值降低效应的综合结果。
