Allen Family Drug, North Allen, Texas, US.
Dermatology and Skin Cancer Surgery Center, North Allen, Texas, US.
Int J Pharm Compd. 2024 Jul-Aug;28(4):271-277.
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease that may have profound effects on the patient's quality of life. A personalized HS combination therapy treatment was prescribed to a 54-year-old female suffering from multiple painful sores, as follows: naltrexone capsules titrated from 0.5 mg up to 4.5 mg; pentoxifylline 5%, rifampin 2%, clindamycin 1%, and glycolic acid topical cream. Clinical improvements were observed using two disease-specific outcome measures: Hurley Staging System and HS Score. The patient's HS improved from Stage II (moderate) to Stage I (mild), and the HS score decreased from 103 points with five anatomical regions reported, to 19 points with only three regions affected. Furthermore, the before and after treatment photographs showed a visible reduction in the number of boils/skin abscesses and an overall recovery. Improvements were also observed across all domains of the patient's self-reported quality of life (Hidradenitis Suppurativa Quality of Life Assessment). The patient did not experience any undesirable effects. Compounded medications may be customized to meet the patient's special needs and may be adjusted throughout the course of treatment to match the patient's individual progress. Although further studies are necessary, this personalized, combination therapy may be a key treatment option in HS.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，可能对患者的生活质量产生深远影响。为一名患有多处疼痛性溃疡的 54 岁女性患者开具了一种个性化的 HS 联合治疗方案，具体如下：纳曲酮胶囊从 0.5 毫克滴定至 4.5 毫克； 5%己酮可可碱、2%利福平、1%克林霉素和 20%甘醇酸乳膏。使用两种特定于疾病的结局测量方法： Hurley 分期系统和 HS 评分，观察到临床改善。患者的 HS 从 II 期（中度）改善到 I 期（轻度），HS 评分从报告的 5 个解剖区域的 103 分降至受影响的仅 3 个区域的 19 分。此外，治疗前后的照片显示，疖子/皮肤脓肿的数量明显减少，整体恢复。患者报告的生活质量（化脓性汗腺炎生活质量评估）的所有领域也都得到了改善。患者没有出现任何不良反应。复方药物可以根据患者的特殊需求进行定制，并在整个治疗过程中进行调整，以适应患者的个体进展。虽然还需要进一步研究，但这种个性化的联合治疗可能是 HS 的一个关键治疗选择。
