Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.
J Nutr Health Aging. 2024 Sep;28(9):100319. doi: 10.1016/j.jnha.2024.100319. Epub 2024 Aug 1.
The relationship between serum uric acid (SUA) levels and brain-related health remains uncertain.
This study aimed to investigate the relationship between SUA levels and some neurodegenerative disorders and brain structure.
A longitudinal study.
384,517 participants who did not have stroke, dementia, and Parkinsonism, with complete urate testes and covariates were included.
Cox proportional hazards models, competing risk models, and restricted cubic spine models were applied.
During the median follow-up time of 12.7 years (interquartile range [IQR]:12.0, 13.5), 7821 (2.0%) participants developed stroke, 5103 (1.3%) participants developed dementia, and 2341 (0.6%) participants developed Parkinsonism. Nonlinear relationships were identified between SUA levels and stroke (J-shaped), dementia, and Parkinsonism (U-shaped). SUA levels of 4.2 mg/dl, 6.4 mg/dl, and 6.6 mg/dl yielded the lowest risk of stroke, dementia, and Parkinsonism, respectively. Besides, we found high SUA levels reduced the volumes of total brain, grey matter, white matter, grey matter in the hippocampus, and hippocampus, but increased lateral-ventricle volume. Inflammation accounted for 9.1% and 10.0% in the association of SUA with stroke and lateral-ventricle volume.
Lower SUA levels increased the risk of Parkinsonism, while both lower and higher SUA levels were positively associated with increased risk of stroke and dementia. Moreover, high SUA levels reduced brain structure volumes. Our findings suggest the association between SUA levels and brain-related disorders and highlight the importance of SUA management.
血清尿酸（SUA）水平与脑相关健康之间的关系仍不确定。
本研究旨在探讨 SUA 水平与某些神经退行性疾病和脑结构之间的关系。
纵向研究。
纳入了 384517 名没有中风、痴呆和帕金森病且尿酸检测完整的参与者，并纳入了协变量。
应用 Cox 比例风险模型、竞争风险模型和限制立方样条模型。
在中位随访时间 12.7 年（四分位距 [IQR]：12.0，13.5）期间，7821 名（2.0%）参与者发生中风，5103 名（1.3%）参与者发生痴呆，2341 名（0.6%）参与者发生帕金森病。SUA 水平与中风（J 形）、痴呆和帕金森病（U 形）之间存在非线性关系。SUA 水平为 4.2mg/dl、6.4mg/dl 和 6.6mg/dl 时，中风、痴呆和帕金森病的风险最低。此外，我们发现高 SUA 水平降低了大脑总容量、灰质、白质、海马灰质和海马的体积，但增加了侧脑室的体积。炎症占 SUA 与中风和侧脑室体积关联的 9.1%和 10.0%。
较低的 SUA 水平增加了帕金森病的风险，而较低和较高的 SUA 水平均与中风和痴呆风险的增加呈正相关。此外，高 SUA 水平降低了脑结构体积。我们的研究结果表明 SUA 水平与脑相关疾病之间存在关联，并强调了 SUA 管理的重要性。
