Department of Thoracic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, People's Republic of China.
Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 201620, People's Republic of China.
Biomed Mater. 2024 Aug 14;19(5). doi: 10.1088/1748-605X/ad6ac6.
The appropriate degradation characteristics of polydioxanone (PDO) are necessary for the safety and effectiveness of stents. This study aimed to investigate the degradation of PDO weaving tracheal stents (PW stents)and. The degradation solution of(SAU),(ECO),(PAE), and control (N) were prepared, and the PW stents were immersed for 12 weeks. Then, the radial support force, weight retention, pH, molecular structure, thermal performance, and morphology were determined. Furthermore, the PW stents were implanted into the abdominal cavity of rabbits, and omentum was embedded. At feeding for 16 weeks, the mechanical properties, and morphology were measured. During the first 8 weeks, the radial support force in all groups was progressively decreased. At week 2, the decline rate of radial support force in the experimental groups was significantly faster compared to the N group, and the difference was narrowed thereafter. The infrared spectrum showed that during the whole degradation process, SAU, ECO and PAE solution did not lead to the formation of new functional groups in PW stents.scanning electron microscope observation showed that SAU and ECO were more likely to gather and multiply at the weaving points of the PW stents, forming colonies.experiments showed that the degradation in the concavity of weaving points of PW stents was more rapid and severe. The radial support loss rate reached more than 70% at week 4, and the radial support force was no longer measurable after week 8. In omentum, multinuclear giant cells and foreign giant cells were found to infiltrate. PW stents have good biocompatibility. The degradation rate of PW stents in the aseptic conditionswas faster than in the bacteriological environment.
聚二氧杂环己酮（PDO）的适当降解特性对于支架的安全性和有效性是必要的。本研究旨在探讨 PDO 编织气管支架（PW 支架）的降解情况。制备了降解溶液（SAU）、（ECO）、（PAE）和对照（N），将 PW 支架浸入其中 12 周。然后，测定了径向支撑力、重量保留率、pH 值、分子结构、热性能和形态。此外，将 PW 支架植入兔的腹腔，并用大网膜包裹。在喂养 16 周后，测量机械性能和形态。在前 8 周内，所有组的径向支撑力逐渐下降。在第 2 周，实验组的径向支撑力下降速度明显快于 N 组，此后差异缩小。红外光谱显示，在整个降解过程中，SAU、ECO 和 PAE 溶液并未导致 PW 支架形成新的官能团。扫描电子显微镜观察显示，SAU 和 ECO 更容易在 PW 支架的编织点聚集和增殖，形成菌落。实验表明，PW 支架编织点凹陷处的降解速度更快、更严重。第 4 周时，径向支撑力损失率达到 70%以上，第 8 周后，径向支撑力无法测量。在大网膜中，发现多核巨细胞和异物巨细胞浸润。PW 支架具有良好的生物相容性。在无菌条件下，PW 支架的降解速度快于细菌环境。
