Pathology Department, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
General Medicine Department, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Exp Cell Res. 2024 Aug 15;441(2):114191. doi: 10.1016/j.yexcr.2024.114191. Epub 2024 Jul 31.
Neutrophil extracellular traps (NETs) are web-like structures composed of cytoplasmic contents, DNA chromatin and various granular proteins released by neutrophils in response to viruses, bacteria, immune complexes and cytokines. Studies have shown that NETs can promote the occurrence, development and metastasis of tumors. In this paper, the mechanism underlying the formation and degradation of NETs and the malignant biological behaviors of NETs, such as the promotion of tumor cell proliferation, epithelial mesenchymal transition, extracellular matrix remodeling, angiogenesis, immune evasion and tumor-related thrombosis, are described in detail. NETs are being increasingly studied as therapeutic targets for tumors. We have summarized strategies for targeting NETs or interfering with NET-cancer cell interactions and explored the potential application value of NETs as biomarkers in cancer diagnosis and treatment, as well as the relationship between NETs and therapeutic resistance.
中性粒细胞胞外诱捕网（NETs）是由中性粒细胞在应对病毒、细菌、免疫复合物和细胞因子时释放的细胞质内容物、DNA 染色质和各种颗粒蛋白组成的网状结构。研究表明，NETs 可以促进肿瘤的发生、发展和转移。本文详细描述了 NETs 的形成和降解机制以及 NETs 的恶性生物学行为，如促进肿瘤细胞增殖、上皮间质转化、细胞外基质重塑、血管生成、免疫逃逸和肿瘤相关血栓形成。NETs 作为肿瘤的治疗靶点正受到越来越多的研究。我们总结了针对 NETs 或干扰 NET-癌细胞相互作用的策略，并探讨了 NETs 作为癌症诊断和治疗生物标志物的潜在应用价值，以及 NETs 与治疗耐药性之间的关系。
