Cukurova University, Faculty of Ceyhan Veterinary Medicine, Department of Veterinary Pharmacology and Toxicology, Adana, Türkiye.
Balikesir University, Faculty of Medicine, Department of Medical Pharmacology, Balikesir, Türkiye; Institute of Health Sciences, Department of Veterinary Pharmacology and Toxicology, Balikesir, Türkiye.
Vet J. 2024 Oct;307:106200. doi: 10.1016/j.tvjl.2024.106200. Epub 2024 Jul 31.
Robenacoxib (RX) is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. This study aimed to evaluate the plasma dispositions and faecal excretion profiles of RX in Alpine and Saanen goats following oral and subcutaneous routes. Two different goat breeds were allocated into two treatment groups concerning the breed. RX was administered subcutaneously to animals at a dose of 4 mg/kg b.w. Following a one-week washout period, RX was administered by oral route to the same animals at the same dose. Heparinized blood samples were collected from all animals before drug administration (0 h) and subsequently up to 24 h. Faecal samples were collected at various times between 8 h and 36 h. The concentrations of RX in plasma and faeces were determined by HPLC. The plasma half-life (T) of RX in Saanen goats (1.21 h) was significantly longer (P < 0.017) than in Alpine goats (0.90 h) after subcutaneous administration. In both goat breeds, statistical differences were observed between subcutaneous and oral administration of RX for T, T, C, AUC, and MRT. Faecal C and T parameters following oral administrations were 0.92 µg/g and 0.85 µg/g at 30 h and at 24 h in Alpine and Saanen goats, respectively. The difference in plasma protein ratio between Alpine and Saanen goats may have affected the T of the drug. NSAIDs are among the drug groups frequently detected in aquatic and terrestrial ecosystems around the world and there are data on the effects of NSAID residues on wildlife and aquatic species. Therefore, revealing the excretion of NSAIDs, which are frequently used in the veterinary field, in faeces and urine should be considered for ecological sustainability.
罗非昔布（RX）是一种昔布类非甾体抗炎药（NSAID）。本研究旨在评估 Alpine 和 Saanen 山羊经口服和皮下途径给药后 RX 的血浆处置和粪便排泄特征。根据品种将两种不同的山羊品种分配到两个治疗组。以 4mg/kg bw 的剂量皮下给动物注射 RX。在一周的洗脱期后，以相同剂量经口服途径给相同动物注射 RX。在给药前（0 小时）和随后最多 24 小时从所有动物采集肝素化血液样本。在 8 小时至 36 小时之间的不同时间采集粪便样本。通过 HPLC 测定血浆和粪便中 RX 的浓度。皮下给药后，Saanen 山羊（1.21 小时）的 RX 血浆半衰期（T）明显长于 Alpine 山羊（0.90 小时）（P < 0.017）。在两种山羊品种中，皮下和口服给药的 RX 的 T、T、C、AUC 和 MRT 均观察到统计学差异。口服给药后 30 小时和 24 小时，Alpine 和 Saanen 山羊粪便中的 C 和 T 参数分别为 0.92μg/g 和 0.85μg/g。Alpine 和 Saanen 山羊之间的血浆蛋白比率差异可能影响了药物的 T。NSAIDs 是世界范围内水生和陆地生态系统中经常检测到的药物组之一，有数据表明 NSAID 残留对野生动物和水生物种的影响。因此，考虑到生态可持续性，应该考虑在粪便和尿液中排泄经常在兽医领域使用的 NSAIDs。
