Department of Pediatrics, Neonatal-Perinatal Medicine, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA.
Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand; Department of Paediatrics, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
Clin Perinatol. 2024 Sep;51(3):565-572. doi: 10.1016/j.clp.2024.04.002. Epub 2024 May 16.
Therapeutic hypothermia is now well established to improve neurodevelopmental outcomes after hypoxic-ischemic encephalopathy (HIE). Although the overall principles of treatment are now well established, many smaller questions are unclear. The potential impact of reversal of hypothermia therapy and the effect of high temperatures on recovery of the neurovascular unit after therapeutic hypothermia for HIE has received relatively little attention. This article will address the effects of hypoxia-ischemia and rewarming and increased temperatures on the neurovascular unit in preclinical and clinical models.
治疗性低温目前已被广泛应用于改善缺氧缺血性脑病（HIE）后的神经发育结局。尽管目前已经明确了治疗的总体原则，但仍有许多较小的问题尚不清楚。治疗性低温治疗中复温的潜在影响以及高温对 HIE 后神经血管单元恢复的影响受到的关注相对较少。本文将讨论缺氧缺血和复温以及温度升高对临床前和临床模型中神经血管单元的影响。
