Watkinson M, Rushton D I, Lunn P G
Trans R Soc Trop Med Hyg. 1985;79(4):448-50. doi: 10.1016/0035-9203(85)90059-8.
Placental biopsies were taken immediately post partum from 65 Gambian mothers who had not received anti-malaria chemoprophylaxis during pregnancy whilst living in an area hyperendemic for Plasmodium falciparum malaria. The biopsies were examined without knowledge of the mothers' health or the outcome of pregnancies. Histologically, they were divided into two groups: those with macrophages containing malarial pigment in the inter-villous spaces, and those without such pathology. Babies with pigmented placentae had a mean (SD) weight for gestational age of 83.3 (10.6)%, which was significantly lower (p less than 0.01) than that of 91.2 (7.7)% in the non-pigmented group. The plasma oestradiol concentrations in the mothers who later delivered pigmented placentae were significantly lower from 32 weeks of gestation onwards, and did not continue to rise in the last trimester as they did in the non-pigmented group. The last trimester appears to be the critical time for protection of the foeto-placental unit against malaria. Anti-malaria chemoprophylaxis should be given to all pregnant women.
从65名冈比亚母亲产后立即采集胎盘活检样本，这些母亲在孕期居住于恶性疟原虫疟疾高度流行地区，且未接受过抗疟疾化学预防。活检样本在不知母亲健康状况及妊娠结局的情况下进行检查。从组织学上看，它们被分为两组：绒毛间隙中有含疟色素巨噬细胞的胎盘，以及无此类病变的胎盘。有色素沉着胎盘的婴儿出生体重相对于胎龄的均值（标准差）为83.3（10.6）%，显著低于无色素沉着组的91.2（7.7）%（p<0.01）。后来娩出有色素沉着胎盘的母亲，从妊娠32周起血浆雌二醇浓度显著降低，且在妊娠晚期不像无色素沉着组那样持续上升。妊娠晚期似乎是保护胎儿 - 胎盘单位免受疟疾侵害的关键时期。所有孕妇均应给予抗疟疾化学预防。
