Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong City, 226001, Jiangsu Province, China.
Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
Sci Rep. 2024 Aug 2;14(1):17899. doi: 10.1038/s41598-024-68134-y.
SLAMF9, a member of the conserved lymphocyte activation molecules family (SLAMF), has been less investigated compared to other SLAMs, especially concerning its implications across various cancer types. In our systematic pan-cancer investigation, we observed elevated SLAMF9 expression in various tumor tissues, which was correlated with reduced patient survival across most malignancies. Correlation analyses further revealed significant associations between SLAMF9 expression and immune cell infiltrates, immune checkpoint inhibitors, tumor mutation load, microsatellite instability, and epithelial-mesenchymal transition (EMT) scores. Cell-based assays demonstrated that SLAMF9 knockdown attenuated the proliferative, motile, and invasive capacities of colorectal cancer (CRC) cells. In a nude mouse xenograft model, suppression of SLAMF9 expression substantially inhibited tumor growth. These findings highlight the potential of SLAMF9 as a prognostic and therapeutic biomarker across tumors, with notable implications for CRC cell proliferation and migration.
SLAMF9 是淋巴细胞激活分子家族（SLAMF）的一个成员，与其他 SLAMs 相比，其研究相对较少，特别是关于其在各种癌症类型中的作用。在我们的系统泛癌症研究中，我们观察到各种肿瘤组织中 SLAMF9 表达升高，这与大多数恶性肿瘤患者的生存时间缩短相关。相关性分析进一步显示，SLAMF9 表达与免疫细胞浸润、免疫检查点抑制剂、肿瘤突变负荷、微卫星不稳定性和上皮-间充质转化（EMT）评分之间存在显著关联。基于细胞的实验表明，SLAMF9 敲低可减弱结直肠癌（CRC）细胞的增殖、迁移和侵袭能力。在裸鼠异种移植模型中，抑制 SLAMF9 表达可显著抑制肿瘤生长。这些发现突出了 SLAMF9 作为跨肿瘤的预后和治疗生物标志物的潜力，对 CRC 细胞增殖和迁移具有重要意义。
