在尸体肾移植中使用环孢素A提高患者及移植物存活率。

Improved patient and graft survival using cyclosporin A in cadaver renal transplantation.

作者信息

Johnson R W

出版信息

Ulster Med J. 1985 Aug;54 Suppl(Suppl):S81-5.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2447967/

Abstract

In two consecutive prospective randomised trials cyclosporin A has been compared with conventional immunosuppressive therapy (azathioprine and steroids) and with cyclosporin combined with steroids. The present report is a 4 year review and includes 165 patients.Cyclosporin A alone had a significant advantage over conventional therapy at both 1 and 3 years (p = 0.02) for both patient and graft survival. No significant difference was seen when cyclosporin was combined with steroids. Nephrotoxicity was the most troublesome side-effect of cyclosporin A - but this resolved spontaneously on withdrawal of the drug.

摘要

在两项连续的前瞻性随机试验中，将环孢素A与传统免疫抑制疗法（硫唑嘌呤和类固醇）以及环孢素与类固醇联合使用进行了比较。本报告是一项为期4年的回顾，包括165名患者。单独使用环孢素A在1年和3年时，在患者和移植物存活率方面均比传统疗法具有显著优势（p = 0.02）。环孢素与类固醇联合使用时未观察到显著差异。肾毒性是环孢素A最麻烦的副作用——但停药后可自发缓解。

相似文献

1

Improved patient and graft survival using cyclosporin A in cadaver renal transplantation.在尸体肾移植中使用环孢素A提高患者及移植物存活率。

Ulster Med J. 1985 Aug;54 Suppl(Suppl):S81-5.

2

Cyclosporin in cadaveric renal transplantation: one-year follow-up of a multicentre trial.

Lancet. 1983 Oct 29;2(8357):986-9.

3

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5

A prospective randomised comparative study on the influence of cyclosporin and azathioprine on renal allograft survival and function.一项关于环孢素和硫唑嘌呤对肾移植存活率和功能影响的前瞻性随机对照研究。

Nephrol Dial Transplant. 1986;1(1):44-9.

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Cyclosporin a as sole immunosuppressive agent in recipients of kidney allografts from cadaver donors. Preliminary results of a European multicentre trial.环孢素A作为尸体供肾移植受者的唯一免疫抑制剂。一项欧洲多中心试验的初步结果。

Lancet. 1982 Jul 10;2(8289):57-60.

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8

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A controlled trial of azathioprine in combination with cyclosporine in cadaveric renal transplantation.硫唑嘌呤联合环孢素用于尸体肾移植的对照试验。

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本文引用的文献

1

Nephrotoxicity of cyclosporin A in bone-marrow transplantation.

Lancet. 1981 Jul 18;2(8238):144-5. doi: 10.1016/s0140-6736(81)90320-2.

2

Nephrotoxicity of cyclosporin A in liver and kidney transplant patients.环孢素A在肝肾移植患者中的肾毒性

Lancet. 1981 Feb 28;1(8218):470-1. doi: 10.1016/s0140-6736(81)91851-1.

3

Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers.环孢素A最初作为唯一的免疫抑制剂应用于34例尸体器官接受者：32例肾移植、2例胰腺移植和2例肝移植。

Lancet. 1979 Nov 17;2(8151):1033-6. doi: 10.1016/s0140-6736(79)92440-1.

4

Cyclosporin A in patients receiving renal allografts from cadaver donors.接受尸体供体肾移植患者使用环孢素A的情况。

Lancet. 1978;2(8104-5):1323-7. doi: 10.1016/s0140-6736(78)91970-0.

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