Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, University of Amsterdam, Amsterdam UMC location AMC, Amsterdam, the Netherlands.
Copenhagen Health Complexity Center, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Sleep Med Rev. 2024 Oct;77:101977. doi: 10.1016/j.smrv.2024.101977. Epub 2024 Jul 14.
Sleep plays an essential role in physiology, allowing the brain and body to restore itself. Despite its critical role, our understanding of the underlying processes in the sleeping human brain is still limited. Sleep comprises several distinct stages with varying depths and temporal compositions. Cerebral blood flow (CBF), which delivers essential nutrients and oxygen to the brain, varies across brain regions throughout these sleep stages, reflecting changes in neuronal function and regulation. This systematic review and meta-analysis assesses global and regional CBF across sleep stages. We included, appraised, and summarized all 38 published sleep studies on CBF in healthy humans that were not or only slightly (<24 h) sleep deprived. Our main findings are that CBF varies with sleep stage and depth, being generally lowest in NREM sleep and highest in REM sleep. These changes appear to stem from sleep stage-specific regional brain activities that serve particular functions, such as alterations in consciousness and emotional processing.
睡眠在生理学中起着至关重要的作用，使大脑和身体得以自我修复。尽管睡眠至关重要，但我们对人类睡眠大脑的潜在过程的理解仍然有限。睡眠由几个不同的阶段组成，每个阶段的深度和时间组成都不同。脑血流（CBF）在这些睡眠阶段在大脑的不同区域变化，反映了神经元功能和调节的变化，为大脑输送必需的营养物质和氧气。本系统综述和荟萃分析评估了整个睡眠阶段的全球和区域 CBF。我们纳入、评估和总结了所有 38 项关于健康人类 CBF 的睡眠研究，这些研究没有或只有轻微的睡眠剥夺（<24 小时）。我们的主要发现是，CBF 随睡眠阶段和深度而变化，通常在 NREM 睡眠中最低，在 REM 睡眠中最高。这些变化似乎源于特定于睡眠阶段的区域脑活动，这些活动具有特定的功能，例如意识和情绪处理的改变。
