Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China; The First People's Hospital of Changde City, Changde, China.
Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China; The First People's Hospital of Changde City, Changde, China.
Child Abuse Negl. 2024 Sep;155:106961. doi: 10.1016/j.chiabu.2024.106961. Epub 2024 Aug 2.
Childhood abuse is associated with an increased risk of migraines. However, the literature on this association is limited.
To determine the pooled effect size of the association between childhood abuse and migraines.
System review and meta-analysis.
A systematic literature search for studies published until September 20, 2023, was performed using the Embase, PubMed, and Web of Science databases. Specifically, original articles reporting the statistical effect size (odds ratio) of the association between childhood abuse and migraines were selected. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using random- or fixed-effects models. Publication bias was examined using funnel plots, and sensitivity analysis was used to explore the stability of the pooled results.
Twelve studies involving 110,776 participants were included. Individuals with childhood abuse (OR = 1.60, 95 % CI: 1.49, 1.71) were at increased risk of migraine when compared with individuals with no childhood abuse. Of the different types of childhood abuse examined, sexual abuse (OR = 1.71, 95 % CI: 1.43, 2.04), physical abuse (OR = 1.47, 95 % CI: 1.38, 1.56), and emotional abuse (OR = 1.71, 95 % CI: 1.52, 1.93) were associated with an increased risk of migraine.
Childhood abuse increases migraine risk. Multifaceted interventions to curb abuse and related behaviors can effectively reduce migraine risk. However, considering that multiple factors, such as obesity and anxiety, are causatively associated with both childhood abuse and migraines, our findings should be interpreted with caution.
儿童期虐待与偏头痛风险增加相关。然而，关于这种关联的文献有限。
确定儿童期虐待与偏头痛之间关联的汇总效应大小。
系统评价和荟萃分析。
使用 Embase、PubMed 和 Web of Science 数据库对截至 2023 年 9 月 20 日发表的研究进行了系统文献检索。具体来说，选择了报告儿童期虐待与偏头痛之间关联的统计学效应大小（比值比）的原始文章。使用随机或固定效应模型计算汇总比值比（OR）和 95%置信区间（CI）。使用漏斗图检查发表偏倚，并进行敏感性分析以探索汇总结果的稳定性。
纳入了 12 项涉及 110776 名参与者的研究。与没有儿童期虐待的个体相比，有儿童期虐待的个体（OR=1.60，95%CI：1.49，1.71）偏头痛风险增加。在所检查的不同类型的儿童期虐待中，性虐待（OR=1.71，95%CI：1.43，2.04）、身体虐待（OR=1.47，95%CI：1.38，1.56）和情绪虐待（OR=1.71，95%CI：1.52，1.93）与偏头痛风险增加相关。
儿童期虐待会增加偏头痛的风险。采取多方面的干预措施来遏制虐待和相关行为，可以有效地降低偏头痛的风险。然而，考虑到肥胖和焦虑等多种因素与儿童期虐待和偏头痛都有因果关系，我们的发现应谨慎解读。
