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多发性硬化症对西班牙女性生殖生活影响的研究:一项在线调查。

Study of the impact of multiple sclerosis on the reproductive life of Spanish women: An online survey.

机构信息

Department of Functional Biology, Physiology, Faculty of Medicine and Health Sciences, University of Oviedo, Oviedo, Spain.

Department of Functional Biology, Physiology, Faculty of Medicine and Health Sciences, University of Oviedo, Oviedo, Spain.

出版信息

Mult Scler Relat Disord. 2024 Oct;90:105789. doi: 10.1016/j.msard.2024.105789. Epub 2024 Jul 30.

DOI:10.1016/j.msard.2024.105789
PMID:39096667
Abstract

BACKGROUND

Women have a higher risk of developing multiple sclerosis (MS) than men. The natural reproductive period from menarche to menopause corresponds to the period of active inflammatory disease in MS. Mothers and pregnant women with MS need information about how their disease may affect pregnancy and breastfeeding.

AIM

The aim was to explore the reproductive factors in an MS-diagnosed population and to identify ways to support patients and their decision-making process.

METHODS

We conducted a cross-sectional, Web-based survey of women living with MS in Asturias (Spain) using a community-based participatory approach.

FINDINGS

Early menarche may predict the onset of MS. Pregnancy improves the general health of patients and reduces the number of relapses. Breastfeeding is often not practised and may cause concern in women. MS does not affect the age of menopause, but it can worsen symptoms. However, menopause does not increase the number of MS relapses.

CONCLUSIONS

MS is increasingly diagnosed at an earlier age, which increases the number of women who become pregnant after being diagnosed with MS. The decrease in MS relapses during pregnancy and the increase during the postpartum period are consistent with previous reports. Women who choose to breastfeed are in the minority due to treatment incompatibility, although some currently used treatments are compatible with breastfeeding. However, there is a lack of information on this which should be investigated.

摘要

背景

女性患多发性硬化症(MS)的风险高于男性。从初潮到绝经的自然生殖期与 MS 中活跃的炎症性疾病时期相对应。患有 MS 的母亲和孕妇需要了解她们的疾病如何影响怀孕和哺乳。

目的

旨在探讨 MS 确诊人群中的生殖因素,并确定支持患者及其决策过程的方法。

方法

我们采用基于社区的参与式方法,对阿斯图里亚斯(西班牙)的 MS 女性患者进行了一项横断面、基于网络的调查。

结果

初潮早可能预示着 MS 的发病。妊娠可改善患者的整体健康状况并减少复发次数。母乳喂养通常未实施,且可能引起女性担忧。MS 不会影响绝经年龄,但可能会使症状恶化。然而,绝经并不会增加 MS 复发的次数。

结论

MS 的确诊年龄越来越早,这增加了诊断后怀孕的女性人数。怀孕期间 MS 复发减少,产后期间复发增加,这与之前的报告一致。由于治疗不兼容,选择母乳喂养的女性较少,尽管目前一些治疗方法与母乳喂养兼容。但是,关于这方面的信息不足,应进行调查。

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