Department of Nursing, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong New District, Shanghai, China.
Department of Cardiology, First Affiliated Hospital of Ji'Nan University, Tianhe District, Guangzhou, Guangdong, China.
Nutr Metab Cardiovasc Dis. 2024 Oct;34(10):2386-2394. doi: 10.1016/j.numecd.2024.05.023. Epub 2024 May 31.
A number of health issues, including high serum uric acid (SUA) and cardiovascular disease (CVD), have been linked to obesity based on observational evidence, though it's currently unclear how these issues are causally related. In order to determine whether obesity mediates this association, we set out to investigate the causal relationship between SUA, obesity, and CVD.
From publicly available genome-wide association studies, we acquired instrumental variables that had a strong correlation to SUA and body mass index (BMI). We employed multiple two-step Mendelian randomization (MR) analyses, using genetic and clinical data from various publicly available biological databases. The mediating role of BMI was examined through mediation analysis. SUA was genetically correlated with BMI [OR = 1.080, 95% CI: 1.024-1.139, P = 0.005]. There was a positive causal effect of SUA on AF [OR = 0.892, 95% CI: 0.804-0.990, P = 0.032], CAD [OR = 0.942, 95% CI: 0.890-0.997, P = 0.037], and EHT [OR = 1.080, 95% CI: 1.024-1.139, P = 0.005]. Among them, BMI mediated the effects of SUA on AF (42.2%; 95% CI, 35.3%-51.9%), CAD (76.3%; 95% CI, 63.4%-92.0%), and EHT (10.0%; 95% CI, 0%-20.0%).
Our research revealed a causal relationship between high SUA exposure and an increased risk of obesity. Additionally, a high SUA level was linked to an increased risk of various CVDs. Given that individuals with high SUA are more likely to be susceptible to AF, CAD, and EHT, attention must be given to their weight status.
基于观察性证据，许多健康问题，包括高血清尿酸（SUA）和心血管疾病（CVD），与肥胖有关，但目前尚不清楚这些问题是如何因果相关的。为了确定肥胖是否介导了这种关联，我们着手研究 SUA、肥胖和 CVD 之间的因果关系。
从公开的全基因组关联研究中，我们获得了与 SUA 和体重指数（BMI）有很强相关性的工具变量。我们利用来自各种公开生物数据库的遗传和临床数据，采用多种两步孟德尔随机化（MR）分析。通过中介分析检验 BMI 的中介作用。SUA 与 BMI 呈遗传相关性[OR=1.080，95%CI：1.024-1.139，P=0.005]。SUA 对 AF [OR=0.892，95%CI：0.804-0.990，P=0.032]、CAD [OR=0.942，95%CI：0.890-0.997，P=0.037]和 EHT [OR=1.080，95%CI：1.024-1.139，P=0.005]有正向因果效应。其中，BMI 介导了 SUA 对 AF（42.2%；95%CI，35.3%-51.9%）、CAD（76.3%；95%CI，63.4%-92.0%）和 EHT（10.0%；95%CI，0%-20.0%）的影响。
我们的研究揭示了高 SUA 暴露与肥胖风险增加之间的因果关系。此外，高 SUA 水平与各种 CVD 的风险增加有关。鉴于高 SUA 个体更容易患 AF、CAD 和 EHT，必须关注他们的体重状况。
