一位看似健康的中国女性反复发作非结核分枝杆菌感染的长期成功管理。
Long-term successfull management of recurrent episodes of nontuberculous mycobacterial infection in an apparently healthy Chinese woman.
机构信息
Vita-Salute San Raffaele University, Via Stamira D'Ancona 20, Milano, 20127, Italy.
Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
出版信息
Ann Clin Microbiol Antimicrob. 2024 Aug 3;23(1):68. doi: 10.1186/s12941-024-00732-0.
BACKGROUND
Disseminated non-tuberculous mycobacteria (dNTM) infections are mostly reported among individuals with an underlying congenital or acquired immunodeficiency or receiving immunosuppressive treatment, but are rarely documented in otherwise healthy subjects.
CASE PRESENTATION
We describe a case of recurrent disseminated mycobacterial infection in an apparently immunocompetent Chinese woman. Mycobacterium szulgai and Mycobacterium avium-complex were identified in distinct episodes. Long-term antimycobacterial therapy was administered given the occurrence of recurrent events when off-treatment. Successful management over more than 10 years and immunologic data are reported.
CONCLUSIONS
This case-report highlights that dNTM should be suspected also among apparently immunocompetent hosts and that thorough assessment of underling immune-impairments is helpful to define patients' management. Long-term antimycobacterial therapy and close monitoring is required to grant successful outcomes in case of recurrent dNTM infections.
背景
播散性非结核分枝杆菌（dNTM）感染主要见于存在潜在先天性或获得性免疫缺陷或接受免疫抑制治疗的个体，但在其他健康个体中很少有记录。
病例介绍
我们描述了一例在免疫功能正常的中国女性中反复发作的播散性分枝杆菌感染。在不同的发作中鉴定出了脓肿分枝杆菌和鸟分枝杆菌复合体。鉴于停药后反复发作，给予长期抗分枝杆菌治疗。报告了 10 多年来成功的管理和免疫数据。
结论
本病例报告强调，dNTM 也应怀疑存在于免疫功能正常的宿主中，彻底评估潜在的免疫功能障碍有助于确定患者的管理。对于反复发作的 dNTM 感染，需要长期抗分枝杆菌治疗和密切监测以获得成功的结果。
Zotero 插件