Department of Nuclear Medicine, Chongqing University Three Gorges Hospital, Wanzhou, 404100, Chongqing, China.
Hell J Nucl Med. 2024 May-Aug;27(2):131-135. doi: 10.1967/s002449912724. Epub 2024 Aug 6.
Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is a multimodal imaging technique that combines PET and CT, utilizing FAP inhibitors as radiotracers. Fibroblast activation protein, a serine protease highly expressed in many epithelial tumor-associated fibroblasts, plays a crucial role in tumor stroma formation and remodeling. Through the detection of FAP expression, FAPI PET/CT facilitates the diagnosis and staging of both benign and malignant pulmonary tumors. In contrast to traditional fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT focusing on glucose metabolism, FAPI PET/CT offers benefits such as enhanced specificity, reduced background noise, accelerated imaging speed, and decreased radiation exposure. This review provides an overview of the progress in applying FAPI PET/CT and F-FDG PET/CT in pulmonary malignancies and discusses current challenges and future prospects.
成纤维细胞激活蛋白抑制剂（FAPI）正电子发射断层扫描/计算机断层扫描（PET/CT）是一种多模态成像技术，它结合了 PET 和 CT，利用 FAP 抑制剂作为放射性示踪剂。成纤维细胞激活蛋白（FAP）是一种丝氨酸蛋白酶，在许多上皮肿瘤相关成纤维细胞中高度表达，在肿瘤基质形成和重塑中发挥关键作用。通过检测 FAP 的表达，FAPI PET/CT 有助于诊断和分期良性和恶性肺肿瘤。与传统的氟-18-氟代脱氧葡萄糖（F-FDG）PET/CT 专注于葡萄糖代谢不同，FAPI PET/CT 具有增强的特异性、降低的背景噪声、更快的成像速度和减少的辐射暴露等优势。本综述介绍了 FAPI PET/CT 和 F-FDG PET/CT 在肺部恶性肿瘤中的应用进展，并讨论了当前的挑战和未来的前景。
