个性化音乐聆听对脑卒中后认知障碍的影响：一项随机对照试验。

Effects of personalized music listening on post-stroke cognitive impairment: A randomized controlled trial.

机构信息

Department of Neurology, Xinglin Branch of the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361022, China.

College of Arts, Xiamen University, Xiamen, Fujian, 361003, China; Ecuadorian Development Research Lab, Daule, Guayas, 090656, Ecuador.

出版信息

Complement Ther Clin Pract. 2024 Nov;57:101885. doi: 10.1016/j.ctcp.2024.101885. Epub 2024 Jul 22.

DOI:10.1016/j.ctcp.2024.101885

PMID:39098085

Abstract

BACKGROUND AND PURPOSE

Previous studies have suggested that music listening has the potential to positively affect cognitive functions and mood in individuals with post-stroke cognitive impairment (PSCI), with a preference for self-selected music likely to yield better outcomes. However, there is insufficient clinical evidence to suggest the use of music listening in routine rehabilitation care to treat PSCI. This randomized control trial (RCT) aims to investigate the effects of personalized music listening on mood improvement, activities of daily living (ADLs), and cognitive functions in individuals with PSCI.

MATERIALS AND METHODS

A total of 34 patients with PSCI were randomly assigned to either the music group or the control group. Patients in the music group underwent a three-month personalized music-listening intervention. The intervention involved listening to a personalized playlist tailored to each individual's cultural, ethnic, and social background, life experiences, and personal music preferences. In contrast, the control group patients listened to white noise as a placebo. Cognitive function, neurological function, mood, and ADLs were assessed.

RESULTS

After three months of treatment, the music group showed significantly higher Montreal Cognitive Assessment (MoCA) scores compared to the control group (p=0.027), particularly in the domains of delayed recall (p=0.019) and orientation (p=0.023). Moreover, the music group demonstrated significantly better scores in National Institutes of Health Stroke Scale (NIHSS) (p=0.008), Barthel Index (BI) (p=0.019), and Zarit Caregiver Burden Interview (ZBI) (p=0.008) compared to the control group. No effects were found on mood as measured by the Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD).

CONCLUSION

Personalized music listening promotes the recovery of cognitive and neurological functions, improves ADLs, and reduces caregiver burden in patients with PSCI.

摘要

背景与目的

既往研究提示，音乐聆听可能对脑卒中后认知障碍（PSCI）患者的认知功能和情绪产生积极影响，而选择患者自身偏好的音乐可能会产生更好的效果。但是，目前尚缺乏临床证据支持将音乐聆听应用于常规康复治疗中以治疗 PSCI。本随机对照试验（RCT）旨在研究个性化音乐聆听对 PSCI 患者情绪改善、日常生活活动（ADL）和认知功能的影响。

材料与方法

共纳入 34 例 PSCI 患者，随机分为音乐组和对照组。音乐组患者接受为期 3 个月的个性化音乐聆听干预，包括聆听根据每位患者的文化、种族和社会背景、生活经历和个人音乐偏好定制的个性化播放列表。对照组患者则聆听白噪声作为安慰剂。评估认知功能、神经功能、情绪和 ADL。

结果

治疗 3 个月后，音乐组的蒙特利尔认知评估（MoCA）评分显著高于对照组（p=0.027），特别是在延迟回忆（p=0.019）和定向（p=0.023）领域。此外，音乐组的美国国立卫生研究院卒中量表（NIHSS）评分（p=0.008）、巴氏指数（BI）（p=0.019）和 Zarit 照顾者负担量表（ZBI）（p=0.008）评分显著优于对照组。汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评估的情绪无显著变化。