Zalcberg J R
Am J Clin Oncol. 1985 Dec;8(6):481-9. doi: 10.1097/00000421-198512000-00007.
This essay presents an overview of tumor localization using radiolabeled monoclonal antibodies. In particular the contribution of three major factors--the antibodies, imaging techniques, and various properties of the tumor--are all considered. Despite the fact that monoclonal antibodies are not truly tumor-specific, the evidence suggests that specific tumor localization is possible. In addition, tumor detection may be improved by the use of antibody fragments. The use of isotopes other than iodine to label immunoglobulins as well as single photon emission computerized tomography may also improve tumor resolution. Tumor heterogeneity and the presence of circulating tumor antigens may be self-limiting, but each of these problems can be overcome. The accurate detection of lymph node metastases is a subject of current study, but if feasible it may represent the major contribution of this imaging technology to clinical medicine.
本文概述了使用放射性标记单克隆抗体进行肿瘤定位的情况。特别考虑了三个主要因素——抗体、成像技术和肿瘤的各种特性——的作用。尽管单克隆抗体并非真正肿瘤特异性的，但证据表明特异性肿瘤定位是可能的。此外，使用抗体片段可能会改善肿瘤检测。使用除碘以外的同位素标记免疫球蛋白以及单光子发射计算机断层扫描也可能提高肿瘤分辨率。肿瘤异质性和循环肿瘤抗原的存在可能会起到自我限制作用，但这些问题均可被克服。准确检测淋巴结转移是当前研究的一个课题，但如果可行，它可能代表这项成像技术对临床医学的主要贡献。
