State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023 China.
State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023 China.
Curr Opin Chem Biol. 2024 Aug;81:102507. doi: 10.1016/j.cbpa.2024.102507. Epub 2024 Aug 3.
Polyketides represent an important class of natural products, renowned for their intricate structures and diverse biological activities. In contrast to common fatty acids, polyketides possess relatively more rigid carbon skeletons, more complex ring systems, and chiral centers. These structural features are primarily achieved through distinctive enzymatic cyclizations and oxidations as tailoring steps. In this opinion, we discuss the recent progress in deciphering the mechanisms of cyclization and oxidation within polyketide biosynthesis. By shedding light on these enzymatic processes, this article seeks to motivate the community to unravel the remaining mysteries surrounding cyclase and oxidase functionalities and to explore novel polyketide natural products through genome mining.
聚酮类化合物是一类重要的天然产物，以其复杂的结构和多样的生物活性而闻名。与常见的脂肪酸不同，聚酮类化合物具有相对更刚性的碳骨架、更复杂的环系统和手性中心。这些结构特征主要通过独特的酶促环化和氧化等修饰步骤来实现。在本观点中，我们讨论了最近在阐明聚酮类生物合成中环化和氧化机制方面的进展。通过揭示这些酶促过程，本文旨在激励研究界阐明剩余的环化酶和氧化酶功能的奥秘，并通过基因组挖掘来探索新的聚酮类天然产物。
