迭代型芳香聚酮合酶的结构酶学：与脂肪酸合酶的关键性比较。
The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases.
机构信息
Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, California 92697, USA; email:
出版信息
Annu Rev Biochem. 2018 Jun 20;87:503-531. doi: 10.1146/annurev-biochem-063011-164509.
Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid synthases (FASs). The focus of this review is to critically compare the properties of FASs with iterative aromatic PKSs, including type II PKSs and fungal type I nonreducing PKSs whose chemical logic is distinct from that of modular PKSs. This review focuses on structural and enzymological studies that reveal both similarities and striking differences between FASs and aromatic PKSs. The potential application of FAS and aromatic PKS structures for bioengineering future drugs and biofuels is highlighted.
聚酮类化合物是一个结构复杂的天然产物大家族，包括具有重要生物活性的化合物。聚酮类化合物是由聚酮合酶（PKSs）生物合成的，多酶复合物是从脂肪酸合酶（FASs）进化而来的。本文的重点是批判性地比较 FAS 和迭代芳香族 PKSs 的特性，包括 II 型 PKS 和真菌 I 型非还原 PKS，其化学逻辑与模块化 PKS 不同。本文重点介绍了结构和酶学研究，这些研究揭示了 FAS 和芳香族 PKS 之间的相似性和显著差异。强调了 FAS 和芳香族 PKS 结构在生物工程未来药物和生物燃料方面的潜在应用。
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