Kara Ali Veysel, Inan Hamza, Durmaz Onder, Ozdemir Ridvan
Faculty of Medicine, Department of Nephrology, Erzincan Binali Yildirim University, Erzincan, Turkey.
Faculty of Medicine, Department of Internal Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Hemodial Int. 2024 Oct;28(4):397-404. doi: 10.1111/hdi.13174. Epub 2024 Aug 4.
We aimed to evaluate the relationship between carotid intima-media thickness (CIMT), which is a known indicator of cardiovascular risk and atherosclerosis, and uric acid level, which may be an easy marker for cardiovascular diseases due to its antioxidant and pro-oxidant properties in hemodialysis patients.
In this cross-sectional study, we evaluated 77 hemodialysis patients. The mean CIMT of these patients was measured and recorded by Doppler ultrasonography. Patients were divided into two groups according to their serum uric acid levels. Correlation analysis and linear regression analysis were used to define the relationship between study parameters.
The mean CIMT levels in the normouricemic group and the hyperuricemic group were 0.95 ± 0.15 and 1.07 ± 0.15, respectively. There was a statistically significant difference between the two groups (p = 0.001). There was a statistically significant and moderate linear correlation between serum uric acid level and mean CIMT (r = 0.402; p = 0.002). Univariate and multivariate linear regression analyses were performed to identify variables that could independently affect the mean CIMT value. According to analysis, uric acid (p < 0.001), hypertension (p = 0.008), albumin (p = 0.029), and C-reactive protein (p = 0.042) were found independent risk factors for mean CIMT value.
We found a significant relationship between serum uric acid level and CIMT, which indicates carotid atherosclerosis. Serum uric acid level is a low-cost laboratory parameter that can be measured in almost all laboratories, and it may be valuable in the hemodialysis patient group to identify patients at high risk of carotid atherosclerosis.
我们旨在评估颈动脉内膜中层厚度（CIMT，一种已知的心血管风险和动脉粥样硬化指标）与尿酸水平之间的关系。尿酸因其在血液透析患者中的抗氧化和促氧化特性，可能是心血管疾病的一个简易标志物。
在这项横断面研究中，我们评估了77例血液透析患者。通过多普勒超声测量并记录这些患者的平均CIMT。根据患者的血清尿酸水平将其分为两组。采用相关性分析和线性回归分析来确定研究参数之间的关系。
正常尿酸血症组和高尿酸血症组的平均CIMT水平分别为0.95±0.15和1.07±0.15。两组之间存在统计学显著差异（p = 0.001）。血清尿酸水平与平均CIMT之间存在统计学显著的中度线性相关性（r = 0.402；p = 0.002）。进行单变量和多变量线性回归分析以确定可独立影响平均CIMT值的变量。根据分析，尿酸（p < 0.001）、高血压（p = 0.008）、白蛋白（p = 0.029）和C反应蛋白（p = 0.042）被发现是平均CIMT值的独立危险因素。
我们发现血清尿酸水平与CIMT之间存在显著关系，这表明颈动脉粥样硬化。血清尿酸水平是一个低成本的实验室参数，几乎在所有实验室都可测量，在血液透析患者组中识别颈动脉粥样硬化高危患者可能具有重要价值。
