阿来替尼成功治疗累及中枢神经系统的ALK阳性组织细胞增多症：一例罕见病例报告 - Suppr

ALK-positive histiocytosis with central nervous system involvement successfully treated with alectinib: a rare case report.

作者信息

Zhao Danqing, Sun Jian, Cao Xinxin

机构信息

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

出版信息

Neurol Sci. 2024 Dec;45(12):5963-5966. doi: 10.1007/s10072-024-07723-1. Epub 2024 Aug 5.

DOI:10.1007/s10072-024-07723-1

PMID:39098856

Abstract

摘要

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ALK-positive histiocytosis with central nervous system involvement successfully treated with alectinib: a rare case report.阿来替尼成功治疗累及中枢神经系统的ALK阳性组织细胞增多症：一例罕见病例报告

Neurol Sci. 2024 Dec;45(12):5963-5966. doi: 10.1007/s10072-024-07723-1. Epub 2024 Aug 5.

ALK-positive histiocytosis: Report of a rare case with exclusive involvement of the central nervous system in an adult woman.ALK 阳性组织细胞增多症：一名成年女性中枢神经系统单独受累的罕见病例报告。

Neuropathology. 2025 Feb;45(1):55-59. doi: 10.1111/neup.13002. Epub 2024 Sep 3.

ALK-positive histiocytosis with disseminated disease responded to alectinib: a case report.ALK 阳性组织细胞增生症伴播散性疾病对艾乐替尼治疗有反应：病例报告。

Ann Palliat Med. 2021 Sep;10(9):10095-10101. doi: 10.21037/apm-21-2117.

Case Report: Rare Systemic and Aggressive ALK-Positive Histiocytosis With Recurrent Pancreatitis Treating by .病例报告：罕见的系统性侵袭性ALK阳性组织细胞增多症伴复发性胰腺炎的治疗。你提供的原文似乎不完整，“Treating by.”后面缺少具体内容。

Front Med (Lausanne). 2022 May 19;9:840407. doi: 10.3389/fmed.2022.840407. eCollection 2022.

Central nervous system relapse in a pediatric anaplastic large cell lymphoma patient with CLTC/ALK translocation treated with alectinib: A case report.用阿来替尼治疗的伴有CLTC/ALK易位的小儿间变性大细胞淋巴瘤患者的中枢神经系统复发：一例报告

World J Clin Cases. 2020 May 6;8(9):1685-1692. doi: 10.12998/wjcc.v8.i9.1685.

Multisystem ALK-Positive Histiocytosis With DCTN1::ALK Fusion in an Adult, Responsive to Alectinib: Case Report and Literature Review.成人多系统ALK阳性组织细胞增多症伴DCTN1::ALK融合，对阿来替尼有反应：病例报告及文献综述

J Cutan Pathol. 2025 Jan;52(1):63-71. doi: 10.1111/cup.14732. Epub 2024 Oct 15.

ALK-rearranged histiocytosis: Report of two cases with involvement of the central nervous system.ALK 重排组织细胞增生症：累及中枢神经系统的两例报告。

Neuropathol Appl Neurobiol. 2021 Oct;47(6):878-881. doi: 10.1111/nan.12739. Epub 2021 Jun 18.

Central nervous system involvement of systemic ALK-positive histiocytosis with fusion.伴有融合的系统性ALK阳性组织细胞增多症的中枢神经系统受累

Radiol Case Rep. 2022 Aug 10;17(10):3867-3870. doi: 10.1016/j.radcr.2022.07.072. eCollection 2022 Oct.

Effect of alectinib versus crizotinib on progression-free survival, central nervous system efficacy and adverse events in ALK-positive non-small cell lung cancer: a systematic review and meta-analysis.阿来替尼对比克唑替尼用于治疗 ALK 阳性非小细胞肺癌的无进展生存期、中枢神经系统疗效和不良反应的效果：一项系统评价和荟萃分析。

Ann Palliat Med. 2020 Jul;9(4):1782-1796. doi: 10.21037/apm-19-643. Epub 2020 Jun 8.

Analysis of central nervous system efficacy in the J-ALEX study of alectinib versus crizotinib in ALK-positive non-small-cell lung cancer.分析在 J-ALEX 研究中艾乐替尼对比克唑替尼用于治疗 ALK 阳性非小细胞肺癌的中枢神经系统疗效。

Lung Cancer. 2018 Jul;121:37-40. doi: 10.1016/j.lungcan.2018.04.015. Epub 2018 Apr 17.

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Diagnosis and management of ALK-positive anaplastic large cell lymphoma in children and adolescents.儿童和青少年间变性大细胞淋巴瘤（ALK 阳性）的诊断和治疗。

Best Pract Res Clin Haematol. 2023 Mar;36(1):101444. doi: 10.1016/j.beha.2023.101444. Epub 2023 Feb 2.

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。

Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.间变性大细胞淋巴瘤激酶阳性组织细胞增生症：一种新的临床病理谱，突出神经受累和对间变性大细胞淋巴瘤激酶抑制的反应。

Blood. 2022 Jan 13;139(2):256-280. doi: 10.1182/blood.2021013338.

Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer.洛拉替尼在既往治疗的 ALK 阳性非小细胞肺癌患者中的脑渗透：CNS 和非 CNS 进展的累积发生率与洛拉替尼相关。

Target Oncol. 2020 Feb;15(1):55-65. doi: 10.1007/s11523-020-00702-4.

Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors.免疫组化检测 ALK 蛋白可识别 APC 突变型髓母细胞瘤，并将 WNT 激活型髓母细胞瘤与其他类型的后颅窝儿童肿瘤区分开来。

Brain Tumor Pathol. 2019 Jan;36(1):1-6. doi: 10.1007/s10014-018-0331-2. Epub 2018 Dec 6.

ALK Expression in Angiomatoid Fibrous Histiocytoma: A Potential Diagnostic Pitfall.ALK 表达在血管肌纤维母细胞瘤中的表达：一个潜在的诊断陷阱。

Am J Surg Pathol. 2019 Jan;43(1):93-101. doi: 10.1097/PAS.0000000000001103.

Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study.阿来替尼对比化疗用于克唑替尼治疗后进展的间变性淋巴瘤激酶（ALK）阳性非小细胞肺癌：来自 III 期 ALUR 研究的结果。

Ann Oncol. 2018 Jun 1;29(6):1409-1416. doi: 10.1093/annonc/mdy121.

Efficiency of Crizotinib on an ALK-Positive Inflammatory Myofibroblastic Tumor of the Central Nervous System: A Case Report.克唑替尼治疗ALK阳性中枢神经系统炎性肌纤维母细胞瘤的疗效：一例报告

Cureus. 2017 Mar 2;9(3):e1068. doi: 10.7759/cureus.1068.

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ALK-positive histiocytosis with central nervous system involvement successfully treated with alectinib: a rare case report.

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