Burke K E, Naughton G, Cassai N
Ann Plast Surg. 1985 Jun;14(6):515-22. doi: 10.1097/00000637-198506000-00004.
The histological fate of an injectable form of type I bovine dermal collagen (Zyderm collagen implant) in the human dermis and subcutaneous tissue has been studied. Sequential biopsies were analyzed by hematoxylin-eosin and Weigert's stains, by immunofluorescence (using a highly specific rabbit anti-Zyderm collagen antibody and a specific anti-human type III collagen antibody), and by electron miscroscopy. The results of this study suggest that the bovine implant material stimulates a host response resulting in implant degradation and replacement by newly generated host collagen.
已对可注射型I型牛真皮胶原蛋白（Zyderm胶原蛋白植入物）在人真皮和皮下组织中的组织学转归进行了研究。通过苏木精-伊红染色和魏格特氏染色、免疫荧光法（使用高度特异性的兔抗Zyderm胶原蛋白抗体和特异性抗人III型胶原蛋白抗体）以及电子显微镜对连续活检样本进行了分析。本研究结果表明，牛植入材料会激发宿主反应，导致植入物降解，并被新生成的宿主胶原蛋白所替代。
