Kamal Zainab, Singh Chandergupt, Tandon Shruti, Lamba Arundeep K, Urs Aadithya B, Rajoria Shivangni
Periodontics, Maulana Azad Institute of Dental Sciences, New Delhi, IND.
Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, IND.
Cureus. 2024 Jul 4;16(7):e63827. doi: 10.7759/cureus.63827. eCollection 2024 Jul.
Oral metastatic lesions are very rare and are often diagnosed at a later stage, complicating treatment. Renal cell carcinoma (RCC) is the third most frequent neoplasm to metastasize to the oral cavity, following breast and lung cancers. These metastatic lesions are usually asynchronous and develop after the initial diagnosis, affecting the overall survival rate. This report describes a known case of RCC with a growth in the mandibular gingiva. Multiple pulmonary and femoral metastases appeared five years after the initial renal lesion. The gingival growth was excised and referred for histopathological examination, which revealed a pleomorphic sarcomatoid cellular morphology. Immunohistochemistry with an array of markers led to the diagnosis of sarcomatoid RCC, a rare high-grade tumor. This case underscores the importance of detailed history-taking, interpretation of clinical findings, and emphasis on histopathological examination to arrive at a conclusive diagnosis.
口腔转移性病变非常罕见，且常于晚期才被诊断出来，这使得治疗变得复杂。肾细胞癌（RCC）是继乳腺癌和肺癌之后，第三常见的转移至口腔的肿瘤。这些转移性病变通常是异时性的，在初始诊断后才出现，影响总体生存率。本报告描述了一例已知的肾细胞癌病例，其下颌牙龈出现肿物。在最初的肾脏病变五年后出现了多发肺和股骨转移。切除牙龈肿物并送去做组织病理学检查，结果显示为多形性肉瘤样细胞形态。一系列标志物的免疫组化检查确诊为肉瘤样肾细胞癌，这是一种罕见的高级别肿瘤。该病例强调了详细病史采集、临床发现解读以及重视组织病理学检查以得出确定性诊断的重要性。
