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提高肾细胞癌诊断和治疗水平的有效策略:生物相容性材料的应用

Effective strategies to enhance the diagnosis and treatment of RCC: The application of biocompatible materials.

作者信息

Li Jinxin, Luo Peng, Liu Shiyang, Fu Meiling, Lin Anqi, Liu Ying, He Ziwei, Qiao Kun, Fang Yu, Qu Le, Yang Kaidi, Wang Kunpeng, Wang Linhui, Jiang Aimin

机构信息

Department of Urology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.

Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China.

出版信息

Mater Today Bio. 2024 Jul 9;27:101149. doi: 10.1016/j.mtbio.2024.101149. eCollection 2024 Aug.

Abstract

Renal cell carcinoma (RCC) is recognized as one of the three primary malignant tumors affecting the urinary system, posing a significant risk to human health and life. Despite advancements in understanding RCC, challenges persist in its diagnosis and treatment, particularly in early detection and diagnosis due to issues of low specificity and sensitivity. Consequently, there is an urgent need for the development of effective strategies to enhance diagnostic accuracy and treatment outcomes for RCC. In recent years, with the extensive research on materials for applications in the biomedical field, some materials have been identified as promising for clinical applications, e.g., in the diagnosis and treatment of many tumors, including RCC. Herein, we summarize the latest materials that are being studied and have been applied in the early diagnosis and treatment of RCC. While focusing on their adjuvant effects, we also discuss their technical principles and safety, thus highlighting the value and potential of their application. In addition, we also discuss the limitations of the application of these materials and possible future directions, providing new insights for improving RCC diagnosis and treatment.

摘要

肾细胞癌(RCC)被认为是影响泌尿系统的三大原发性恶性肿瘤之一,对人类健康和生命构成重大风险。尽管在肾细胞癌的认识方面取得了进展,但其诊断和治疗仍面临挑战,特别是在早期检测和诊断方面,因为存在特异性和敏感性较低的问题。因此,迫切需要制定有效的策略来提高肾细胞癌的诊断准确性和治疗效果。近年来,随着对生物医学领域应用材料的广泛研究,一些材料已被确定具有临床应用前景,例如在包括肾细胞癌在内的许多肿瘤的诊断和治疗中。在此,我们总结了正在研究并已应用于肾细胞癌早期诊断和治疗的最新材料。在关注其辅助作用的同时,我们还讨论了它们的技术原理和安全性,从而突出其应用的价值和潜力。此外,我们还讨论了这些材料应用的局限性以及可能的未来方向,为改善肾细胞癌的诊断和治疗提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec9/11296058/04865a865274/ga1.jpg

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