Chawki Sylvain, Leturque Nicolas, Minier Marine, Gabassi Audrey, Foubert Valérie, Charreau Isabelle, Cua Eric, Pialoux Gilles, Meyer Laurence, Molina Jean-Michel, Delaugerre Constance
Département de Maladies Infectieuses, Hôpitaux Saint Louis et Lariboisière, AP-HP, F-75010 Paris, , France.
Université Paris Cité, Biology of Emerging Viruses Team, INSERM U-944, F-75010 Paris, France.
Open Forum Infect Dis. 2024 Jul 18;11(8):ofae400. doi: 10.1093/ofid/ofae400. eCollection 2024 Aug.
Risk factors for cytomegalovirus (CMV) acquisition in men having sex with men remain unclear. Seroprevalence, incidence, risk factors and shedding of CMV were analyzed among participants enrolled in the HIV pre-exposure prophylaxis IPERGAY-ANRS trial. Among the 417 participants tested, 382 were seropositive at baseline (prevalence of 91.6%; 95%CI[88.5-94.1]) and 10/35 seroconverted during the study (incidence of 17.1 per 100 person-years; 95%CI[8.2-31.3]). A high number of sexual partners was independently associated with CMV seroprevalence. Shedding among CMV-seroconverters was reported for 6/9 and 2/9 at the oral and anal levels, respectively. Our data supports transmission of CMV during sexual contacts.
STUDY PART OF THE ANRS-IPERGAY CLINICAL TRIAL: ClinicalTrials.gov number, NCT01473472.
男男性行为者感染巨细胞病毒（CMV）的危险因素仍不清楚。在参与HIV暴露前预防IPERGAY-ANRS试验的参与者中，分析了CMV的血清阳性率、发病率、危险因素及病毒脱落情况。在417名接受检测的参与者中，382人在基线时血清呈阳性（阳性率为91.6%；95%置信区间[88.5 - 94.1]），35人中有10人在研究期间血清阳转（发病率为每100人年17.1例；95%置信区间[8.2 - 31.3]）。性伴侣数量多与CMV血清阳性独立相关。据报告，CMV血清阳转者中，口腔和肛门部位病毒脱落的比例分别为6/9和2/9。我们的数据支持CMV在性接触过程中的传播。
ANRS-IPERGAY临床试验的研究部分：ClinicalTrials.gov编号，NCT01473472。
