Tang Guo, Li Hao, Liang Chen, Chen Enqiang
Emergency Departments of West China Hospital, Sichuan University, Cheng Du, Sichuan, China.
Department of Nephrology of West China Hospital, Sichuan University, Cheng Du, Sichuan, China.
IDCases. 2024 Jul 4;37:e02022. doi: 10.1016/j.idcr.2024.e02022. eCollection 2024.
Cryptococcus neoformans is a global invasive mycosis that is known to cause significant morbidity and mortality. It is commonly observed that individuals with compromised immune systems are more prone to developing cryptococcal meningitis. Although ocular involvement is rare, previous studies have indicated that ocular lesions precede symptomatic meningitis in only 27 % of patients with central nervous system involvement. Intraocular infections typically manifest as chorioretinopathy and vitreous inflammation, often leading to severe vision loss. In this case, we present the clinical details of a 57-year-old immunocompetent woman who visited the ophthalmology department of West China Hospital of Sichuan University with a progressive loss of vision in her right eye. After a thorough evaluation, she was diagnosed with fungal endophthalmitis, and subsequently initiated on appropriate induction anti-fungal therapy for cryptococcal meningoencephalitis. This case highlights the importance of early recognition and treatment, which can potentially improve the prognosis for patients.
新型隐球菌是一种全球性侵袭性真菌病，已知会导致严重的发病率和死亡率。通常观察到，免疫系统受损的个体更容易发生隐球菌性脑膜炎。虽然眼部受累很少见，但先前的研究表明，在仅27%的中枢神经系统受累患者中，眼部病变先于症状性脑膜炎出现。眼内感染通常表现为脉络膜视网膜炎和玻璃体炎症，常导致严重视力丧失。在本病例中，我们介绍了一名57岁免疫功能正常女性的临床细节，她因右眼视力逐渐下降就诊于四川大学华西医院眼科。经过全面评估，她被诊断为真菌性眼内炎，随后开始接受针对隐球菌性脑膜脑炎的适当诱导抗真菌治疗。该病例强调了早期识别和治疗的重要性，这可能会改善患者的预后。
