Al-Regaiey Khalid A, Iqbal Muhammad, Alzaid Mohammed A, Alkaoud Osama A, Alhadyani Mohammed A, Alagel Osama A, Alshehri Salem S, Altamimi Ibraheem, Alsofayan Saud M
Physiology, King Saud University, Riyadh, SAU.
Medicine, King Saud University, Riyadh, SAU.
Cureus. 2024 Aug 4;16(8):e66122. doi: 10.7759/cureus.66122. eCollection 2024 Aug.
Background and objectives Obesity is a major global health concern linked with increased risk of chronic diseases. This study aimed to assess the levels of fibroblast growth factor 21 (FGF21) in subjects with obesity after gastric sleeve surgery and explore its correlation with lipid and glycemic parameters. Methods This retrospective cohort study included 28 obese male subjects aged 25 to 50 years, undergoing gastric sleeve surgery. Plasma levels of FGF21 were measured by enzyme-linked immunosorbent assay (ELISA) before and six to 12 months after surgery. Other parameters including body mass index (BMI), fasting glucose, lipid profile, and insulin were also assessed and homeostatic model assessment (HOMA) was used to estimate insulin resistance. Results There was a significant increase in systemic FGF21 levels after surgery (45.12 vs. 126.16 pg/mL, p = 0.007). There was also a notable reduction in BMI (51.55 vs. 39.14, p < 0.001), insulin levels (20.06 vs. 8.85 mIU/L, p < 0.001), HOMA scores (6.94 to 2.49, p < 0.001), and glucose levels (7.33 vs. 6.08, p = 0.039). Lipid profile analysis post-surgery showed an increase in total cholesterol (4.38 vs. 5.09 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.88 vs. 1.52 mmol/L, p < 0.001), with a decrease in triglycerides (1.75 vs. 1.01 mmol/L, p = 0.007). FGF21 positively correlated with growth hormone (GH), p = 0.0015, r = 0.59, and with insulin like growth factor 1 (IGF-1), p = 0.03, r = 0.431. Conclusion FGF21 levels were increased following gastric sleeve surgery in obese male patients and were positively correlated with growth hormone and insulin IGF-1. These findings provide insights into the metabolic alterations following bariatric surgery and highlight the potential role of FGF21 as an important molecule in obesity management and treatment.
肥胖是一个主要的全球健康问题，与慢性病风险增加相关。本研究旨在评估胃袖状切除术治疗肥胖患者后成纤维细胞生长因子21（FGF21）的水平，并探讨其与脂质和血糖参数的相关性。方法：本回顾性队列研究纳入了28名年龄在25至50岁之间接受胃袖状切除术的肥胖男性受试者。在手术前以及术后6至12个月，采用酶联免疫吸附测定（ELISA）法测量血浆FGF21水平。还评估了其他参数，包括体重指数（BMI）、空腹血糖、血脂谱和胰岛素，并使用稳态模型评估（HOMA）来估计胰岛素抵抗。结果：术后全身FGF21水平显著升高（45.12对126.16 pg/mL，p = 0.007）。BMI（51.55对39.14，p < 0.001）、胰岛素水平（20.06对8.85 mIU/L，p < 0.001）、HOMA评分（6.94至2.49，p < 0.001）和血糖水平（7.33对6.08，p = 0.039）也有显著降低。术后血脂谱分析显示总胆固醇升高（4.38对5.09 mmol/L，p < 0.001）和高密度脂蛋白（HDL）升高（0.88对1.52 mmol/L，p < 0.001），甘油三酯降低（1.75对1.01 mmol/L，p = 0.007）。FGF21与生长激素（GH）呈正相关，p = 0.0015，r = 0.59，与胰岛素样生长因子1（IGF-1）呈正相关，p = 0.03，r = 0.431。结论：肥胖男性患者接受胃袖状切除术后FGF21水平升高，且与生长激素和胰岛素IGF-1呈正相关。这些发现为减肥手术后的代谢改变提供了见解，并突出了FGF21作为肥胖管理和治疗中重要分子的潜在作用。
