Alvey Lauren, Tabei Seyed Sajjad, Baas Wesley
Division of Urology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Transl Androl Urol. 2024 Jul 31;13(7):1297-1301. doi: 10.21037/tau-24-94. Epub 2024 Jul 11.
Stuttering priapism is recurrent, self-limited episodes of sustained penile erection and is common in patients with sickle cell disease (SCD). Prevention of stuttering priapism is important to avoid progression to episodes of ischemic priapism which can cause erectile dysfunction. Priapism has been shown to be associated with increased nocturnal hypoxemia in patients with SCD.
A 43-year-old male with nocturnal episodes of stuttering priapism that was refractory to treatment with multiple medications was found to have obstructive sleep apnea (OSA). Following treatment of this condition with a continuous positive airway pressure (CPAP), the patient had immediate symptom relief and has had three months without an episode of priapism.
OSA should be considered as an underlying cause of nocturnal stuttering priapism in patients with SCD, particularly in patients who present with stuttering priapism later in life or patients who present strictly with nocturnal episodes. Appropriate management of OSA can significantly decrease the incidence of stuttering priapism in patients with SCD.
间歇性阴茎异常勃起是阴茎持续勃起的反复、自限性发作，在镰状细胞病（SCD）患者中很常见。预防间歇性阴茎异常勃起对于避免发展为缺血性阴茎异常勃起发作很重要，后者可导致勃起功能障碍。阴茎异常勃起已被证明与SCD患者夜间低氧血症增加有关。
一名43岁男性，夜间发作间歇性阴茎异常勃起，多种药物治疗无效，被发现患有阻塞性睡眠呼吸暂停（OSA）。采用持续气道正压通气（CPAP）治疗该疾病后，患者症状立即缓解，且已有三个月未出现阴茎异常勃起发作。
OSA应被视为SCD患者夜间间歇性阴茎异常勃起的潜在病因，尤其是那些在生命后期出现间歇性阴茎异常勃起的患者或仅表现为夜间发作的患者。对OSA进行适当管理可显著降低SCD患者间歇性阴茎异常勃起的发生率。
