Yu Xiaomeng, Cheng Mosong, Zheng Jindan
Departments of Obstetrics, Women and Children's Hospital of Jinzhou, Jinzhou, Liaoning, China.
Departments of Surgery, Jinzhou Second Hospital, Jinzhou, Liaoning, China.
Front Psychiatry. 2024 Jul 19;15:1312117. doi: 10.3389/fpsyt.2024.1312117. eCollection 2024.
To explore the potential causal associations between coeliac disease(CD) and postpartum depression(PPD) by using two-sample Mendelian randomization(MR) analysis.
The IEU OPEN GWAS project was utilized to identify genetic loci strongly associated with CD as instrumental variables (IVs), and MR analysis was performed using inverse variance weighting(IVW), weighted median, weighted model, and MR-Egger. MR analyses were used to examine whether there was a link between CD and PPD, with an OR and 95% CI. Meanwhile, the relationship between CD and depression(DP) was analyzed using MR. The sensitivity analysis was conducted using MR-Egger intercept analysis, Cochran's Q test, and leave-one-out analysis.
From the GWAS online database, 13 single-nucleotide polymorphisms (SNPs) were chosen as IVs. The IVW results showed a relationship between PPD and a genetically predicted risk of developing CD (OR = 1.022, 95% CI: 1.001-1.044, P = 0.043). However, the presence of DP was not linked with CD (OR=0.991, 95% CI: 0.978-1.003, P=0.151). Potential horizontal pleiotropy was not discovered using MR-Egger intercept analysis (PPD: P=0.725; DP: P=0.785), and Cochran's Q test for heterogeneity revealed no significant heterogeneity (PPD: P=0.486; DP: P=0.909). A leave-one-out analysis found that individual SNPs had minimal effect on overall causal estimations.
MR research discovered a link between CD and PPD.
通过两样本孟德尔随机化（MR）分析探讨乳糜泻（CD）与产后抑郁症（PPD）之间的潜在因果关联。
利用IEU OPEN GWAS项目确定与CD密切相关的基因位点作为工具变量（IVs），并采用逆方差加权法（IVW）、加权中位数法、加权模型法和MR-Egger法进行MR分析。MR分析用于检验CD与PPD之间是否存在关联，并计算比值比（OR）和95%置信区间（CI）。同时，使用MR分析CD与抑郁症（DP）之间的关系。采用MR-Egger截距分析、Cochran's Q检验和留一法分析进行敏感性分析。
从GWAS在线数据库中选择了13个单核苷酸多态性（SNP）作为IVs。IVW结果显示PPD与遗传预测的患CD风险之间存在关联（OR = 1.022，95% CI：1.001 - 1.044，P = 0.043）。然而，DP的存在与CD无关联（OR = 0.991，95% CI：0.978 - 1.003，P = 0.151）。使用MR-Egger截距分析未发现潜在的水平多效性（PPD：P = 0.725；DP：P = 0.785），Cochran's Q异质性检验未显示显著异质性（PPD：P = 0.486；DP：P = 0.909）。留一法分析发现单个SNP对总体因果估计的影响极小。
MR研究发现CD与PPD之间存在关联。
