Westcott O, Dorsch S, Roser B
J Immunol. 1979 Oct;123(4):1478-83.
PVG rats bearing a transplantable T cell leukemia were treated with large inocula of lymphoid cells from AUG rats sensitized either against the leukemia or against PVG lymphocytes. AUG and PVG bear identical Ag-B antigens but differ at minor loci, including the Pta loci, which code for differentiation antigens expressed only on peripheral T lymphocytes. Treatment with AUG cells immune to either the PVG leukemia or normal PVG cells resulted in prolonged survival of leukemic rats, a profound but ephemeral leukopenia and prolonged disappearance of leukemic cells from lymphoid tissue. All treated animals, however, eventually died with large, discrete deposits of leukemic cells in both hard and soft tissues. Despite the deliberate mismatching of host and donor cells for minor transplanation antigens, no evidence of GVH symptoms was observed in treated rats. This was interpreted as a result of directing the adoptive immune response to antigens of restricted distribution, i.e., on leukocytes and not on somatic cells.
携带可移植性T细胞白血病的PVG大鼠，用来自对白血病或PVG淋巴细胞致敏的AUG大鼠的大量淋巴细胞接种物进行治疗。AUG和PVG具有相同的Ag-B抗原，但在包括Pta位点在内的次要位点存在差异，Pta位点编码仅在外周T淋巴细胞上表达的分化抗原。用对PVG白血病或正常PVG细胞免疫的AUG细胞治疗，导致白血病大鼠存活期延长、严重但短暂的白细胞减少以及白血病细胞从淋巴组织中长时间消失。然而，所有接受治疗的动物最终都死于硬组织和软组织中大量离散的白血病细胞沉积。尽管宿主和供体细胞在次要移植抗原方面有意不匹配，但在接受治疗的大鼠中未观察到移植物抗宿主（GVH）症状的证据。这被解释为将过继免疫反应导向分布受限的抗原的结果，即针对白细胞而非体细胞上的抗原。
