• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

作者信息

Tsai Cheng-Hsuan, Lai Tai-Shuan, Lin Yen-Hung

机构信息

Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.

National Taiwan University Hospital Primary Aldosteronism Center Taipei Taiwan.

出版信息

J Am Heart Assoc. 2024 Aug 6;13(15):e036496. doi: 10.1161/JAHA.124.036496. Epub 2024 Aug 5.

DOI:10.1161/JAHA.124.036496
PMID:39101512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11964005/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/11964005/e8f74754d7b2/JAH3-13-e036496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/11964005/e8f74754d7b2/JAH3-13-e036496-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15b/11964005/e8f74754d7b2/JAH3-13-e036496-g001.jpg

相似文献

1
Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?通过全基因组关联研究和孟德尔随机化揭示原发性醛固酮增多症中心血管负担的因果关系：一种可能的解决方案？
J Am Heart Assoc. 2024 Aug 6;13(15):e036496. doi: 10.1161/JAHA.124.036496. Epub 2024 Aug 5.
2
Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.原发性醛固酮增多症与心血管结局风险：全基因组关联和孟德尔随机化研究。
J Am Heart Assoc. 2024 Aug 6;13(15):e034180. doi: 10.1161/JAHA.123.034180. Epub 2024 Aug 5.
3
Primary Aldosteronism Influences Cardiac Structure, Function, and Disease Risk: Evidence From Mendelian Randomization Analysis.原发性醛固酮增多症影响心脏结构、功能和疾病风险：来自孟德尔随机分析的证据。
J Clin Hypertens (Greenwich). 2024 Nov;26(11):1301-1309. doi: 10.1111/jch.14912. Epub 2024 Oct 7.
4
Investigating the causal relationship between rheumatoid arthritis and cardiovascular disease: A Mendelian randomization study.探究类风湿性关节炎与心血管疾病之间的因果关系：一项孟德尔随机化研究。
Clin Rheumatol. 2025 Mar;44(3):1057-1067. doi: 10.1007/s10067-025-07357-4. Epub 2025 Feb 6.
5
Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study.乳酸与心血管疾病风险的关联：一项两样本孟德尔随机化研究
Vasc Health Risk Manag. 2024 Dec 6;20:541-551. doi: 10.2147/VHRM.S488424. eCollection 2024.
6
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study.评估饮酒、吸烟与心血管疾病之间的关系：多变量孟德尔随机化研究。
PLoS Med. 2020 Dec 4;17(12):e1003410. doi: 10.1371/journal.pmed.1003410. eCollection 2020 Dec.
7
From genome-wide association studies to Mendelian randomization: novel opportunities for understanding cardiovascular disease causality, pathogenesis, prevention, and treatment.从全基因组关联研究到孟德尔随机化：理解心血管疾病因果关系、发病机制、预防和治疗的新机遇。
Cardiovasc Res. 2018 Jul 15;114(9):1192-1208. doi: 10.1093/cvr/cvy045.
8
Genetically predicted hypothyroidism, thyroid hormone treatment, and the risk of cardiovascular diseases: a mendelian randomization study.基于遗传预测的甲状腺功能减退症、甲状腺激素治疗与心血管疾病风险：一项孟德尔随机研究。
BMC Cardiovasc Disord. 2024 Sep 10;24(1):479. doi: 10.1186/s12872-024-04132-2.
9
Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data.妊娠期糖尿病与未来心血管疾病：基于性别特异性遗传数据的关联
Eur Heart J. 2024 Dec 23;45(48):5156-5167. doi: 10.1093/eurheartj/ehae706.
10
Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis.阻塞性睡眠呼吸暂停与阿尔茨海默病和心血管疾病的因果关联：一项双向孟德尔随机分析。
J Am Heart Assoc. 2024 Sep 17;13(18):e033850. doi: 10.1161/JAHA.123.033850. Epub 2024 Sep 11.

本文引用的文献

1
Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.原发性醛固酮增多症与心血管结局风险：全基因组关联和孟德尔随机化研究。
J Am Heart Assoc. 2024 Aug 6;13(15):e034180. doi: 10.1161/JAHA.123.034180. Epub 2024 Aug 5.
2
Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies.原发性醛固酮增多症的遗传风险及其对高血压的贡献：全基因组关联研究的跨祖先荟萃分析。
Circulation. 2023 Apr 4;147(14):1097-1109. doi: 10.1161/CIRCULATIONAHA.122.062349. Epub 2023 Feb 21.
3
CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity.
CASZ1：一种有潜力的调节醛固酮生物合成和盐皮质激素受体活性的因子。
Hypertens Res. 2023 Feb;46(2):417-420. doi: 10.1038/s41440-022-01131-8. Epub 2022 Dec 16.
4
Identification of risk loci for primary aldosteronism in genome-wide association studies.在全基因组关联研究中识别原发性醛固酮增多症的风险基因座。
Nat Commun. 2022 Sep 3;13(1):5198. doi: 10.1038/s41467-022-32896-8.
5
Aldosterone as a Mediator of Cardiovascular Damage.醛固酮作为心血管损伤的介质。
Hypertension. 2022 Sep;79(9):1899-1911. doi: 10.1161/HYPERTENSIONAHA.122.17964. Epub 2022 Jun 29.
6
Left ventricular remodeling and dysfunction in primary aldosteronism.原发性醛固酮增多症中的左心室重构和功能障碍。
J Hum Hypertens. 2021 Feb;35(2):131-147. doi: 10.1038/s41371-020-00426-y. Epub 2020 Oct 16.
7
miRNA-203 Modulates Aldosterone Levels and Cell Proliferation by Targeting Wnt5a in Aldosterone-Producing Adenomas.miRNA-203 通过靶向醛固酮瘤中的 Wnt5a 调节醛固酮水平和细胞增殖。
J Clin Endocrinol Metab. 2018 Oct 1;103(10):3737-3747. doi: 10.1210/jc.2018-00746.
8
Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study.经医学治疗的原发性醛固酮增多症的心脏代谢结局和死亡率：一项回顾性队列研究。
Lancet Diabetes Endocrinol. 2018 Jan;6(1):51-59. doi: 10.1016/S2213-8587(17)30367-4. Epub 2017 Nov 9.
9
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis.原发性醛固酮增多症与原发性高血压的心血管事件和靶器官损害的比较：系统评价和荟萃分析。
Lancet Diabetes Endocrinol. 2018 Jan;6(1):41-50. doi: 10.1016/S2213-8587(17)30319-4. Epub 2017 Nov 9.
10
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.PKA 抑制肾上腺皮质分带中的 WNT 信号传导，防止恶性肿瘤的发展。
Nat Commun. 2016 Sep 14;7:12751. doi: 10.1038/ncomms12751.