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衰老科学:从健康长寿到虚弱的连续统。

Geroscience in the continuum from healthy longevity to frailty.

机构信息

Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Cluster of Excellence-Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.

出版信息

Z Gerontol Geriatr. 2024 Aug;57(5):361-364. doi: 10.1007/s00391-024-02331-2. Epub 2024 Aug 5.

DOI:10.1007/s00391-024-02331-2
PMID:39102046
Abstract

The socioeconomic and technological developments of the past decades have enabled unique progress associated to increased life expectancy and better health for a large part of the world's population; however, multimorbidity, frailty and disability are also on the rise. Geroscience as the new biology of aging is based on the evidence that the main risk factor for noncommunicable chronic diseases (NCD) is the aging process; however, its technology is mostly used for the scientific study of longevity and its interaction with aging medicine and geriatrics is still limited. In this perspective, the need for a tighter exchange between geroscience and geriatrics for longer health span and intrinsic capacity is discussed in the context of existing evidence and knowledge gaps.

摘要

过去几十年的社会经济和技术发展使世界上很大一部分人口的预期寿命延长,健康状况得到改善;然而,多种疾病、虚弱和残疾的发病率也在上升。衰老生物学是老年医学的新生物学,它基于这样一个证据,即非传染性慢性疾病(NCD)的主要风险因素是衰老过程;然而,其技术主要用于对长寿及其与衰老医学和老年病学的相互作用的科学研究,其应用仍然有限。从这一角度出发,根据现有证据和知识差距,讨论了衰老生物学与老年医学之间更紧密的交流对于延长健康寿命和内在能力的必要性。

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Geroscience in the continuum from healthy longevity to frailty.衰老科学:从健康长寿到虚弱的连续统。
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本文引用的文献

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Biomarkers of aging for the identification and evaluation of longevity interventions.衰老生物标志物用于鉴定和评估长寿干预措施。
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Blood Biomarkers for Healthy Aging.用于健康老龄化的血液生物标志物。
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Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality.多种器官系统的异质性衰老与慢性疾病和死亡率的预测。
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