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锝-99m亚甲基二膦酸盐单光子发射计算机断层扫描/计算机断层扫描骨显像对复发性多软骨炎早期诊断的临床价值:附5例报告

Clinical value of Tc-99m MDP SPECT/CT bone imaging for early diagnosis of Relapsing Polychondritis: a report of 5 cases.

作者信息

Wang Zilin, Tian Yihan, Ji Yanhui, Liu Tong, Wen Shiqi, Wang Peng, Hu Jie, Li Wei

机构信息

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.

出版信息

EJNMMI Res. 2024 Aug 5;14(1):71. doi: 10.1186/s13550-024-01120-7.

DOI:10.1186/s13550-024-01120-7
PMID:39102057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300770/
Abstract

BACKGROUND

Relapsing Polychondritis(RP) is a rare rheumatic immune disease. As with most diseases, if intervention is delayed, the patient's prognosis is worse. Currently, the diagnostic criteria used in clinical practice do not include CT, PET/CT, SPECT/CT and other new imaging examinations that have developed rapidly in recent years. However, these examinations have some special manifestations for RP, which can help clinicians diagnose RP earlier and distinguish it from other diseases.

CASE PRESENTATION

These five RP patients all had respiratory symptoms such as cough and wheezing as the first symptom, which could not be diagnosed in time according to the previous diagnostic criteria. The clinical data of the five patients are listed in Table 1. The relatively specific manifestations of SPECT/CT examination provided clinicians with very valuable clues to help them advance the diagnosis time.

CONCLUSIONS

The application of SPECT/CT bone imaging in early diagnosing RP proves to be effective, enabling clinicians to intervene promptly and enhance the overall well-being and quality of life for individuals affected by this condition.

摘要

背景

复发性多软骨炎(RP)是一种罕见的风湿免疫性疾病。与大多数疾病一样,如果干预延迟,患者的预后会更差。目前,临床实践中使用的诊断标准不包括近年来迅速发展的CT、PET/CT、SPECT/CT等新型影像学检查。然而,这些检查对RP有一些特殊表现,有助于临床医生更早地诊断RP并将其与其他疾病区分开来。

病例介绍

这5例RP患者均以咳嗽、喘息等呼吸道症状为首发症状,按照以往诊断标准无法及时确诊。5例患者的临床资料见表1。SPECT/CT检查的相对特异性表现为临床医生提供了非常有价值的线索,有助于提前诊断时间。

结论

SPECT/CT骨显像在RP早期诊断中的应用被证明是有效的,使临床医生能够及时进行干预,提高受此病影响个体的整体健康水平和生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/5b88ad237cf5/13550_2024_1120_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/272f368ef6ac/13550_2024_1120_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/50c15562b52a/13550_2024_1120_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/60799a743e96/13550_2024_1120_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/3825fa5a0d75/13550_2024_1120_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/30acecb9fdb1/13550_2024_1120_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/5b88ad237cf5/13550_2024_1120_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/272f368ef6ac/13550_2024_1120_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/50c15562b52a/13550_2024_1120_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/60799a743e96/13550_2024_1120_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/3825fa5a0d75/13550_2024_1120_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/30acecb9fdb1/13550_2024_1120_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be87/11300770/5b88ad237cf5/13550_2024_1120_Fig6_HTML.jpg

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Arthritis Res Ther. 2019 Dec 12;21(1):282. doi: 10.1186/s13075-019-2083-8.
2
Relapsing polychondritis patients were divided into three subgroups: patients with respiratory involvement (R subgroup), patients with auricular involvement (A subgroup), and overlapping patients with both involvements (O subgroup), and each group had distinctive clinical characteristics.复发性多软骨炎患者被分为三个亚组:有呼吸道受累的患者(R亚组)、有耳部受累的患者(A亚组)以及同时有两种受累情况的重叠患者(O亚组),且每组都有独特的临床特征。
Medicine (Baltimore). 2018 Oct;97(42):e12837. doi: 10.1097/MD.0000000000012837.
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Rheumatol Int. 2018 Nov;38(11):2095-2101. doi: 10.1007/s00296-018-4121-2. Epub 2018 Aug 6.
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Relapsing Polychondritis: An Updated Review.复发性多软骨炎:最新综述
Biomedicines. 2018 Aug 2;6(3):84. doi: 10.3390/biomedicines6030084.
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