腹腔内注射卡铂的I期研究及药代动力学
Phase I study and pharmacokinetics of intraperitoneal carboplatin.
作者信息
McVie J G, ten Bokkel Huinink W, Dubbelman R, Franklin H, van der Vijgh W, Klein I
出版信息
Cancer Treat Rev. 1985 Sep;12 Suppl A:35-41. doi: 10.1016/0305-7372(85)90016-7.
PMID:3910220
Abstract
In the early stages of this phase I study the tolerance of carboplatin intraperitoneally was good. Pharmacokinetic profiles suggest a possible therapeutic advantage for giving the drug intraperitoneally for the treatment of tumour nodules situated in the peritoneum. The extent of penetration of carboplatin through tumour nodules has not yet been assessed but tumour nodules are being processed for nuclear activation analysis.
摘要
在这项I期研究的早期阶段，卡铂腹腔内给药的耐受性良好。药代动力学研究表明，对于治疗位于腹膜的肿瘤结节，腹腔内给药可能具有治疗优势。尚未评估卡铂在肿瘤结节中的渗透程度，但正在对肿瘤结节进行核活化分析。
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