DR3与金制剂或硫普罗宁所致血小板减少症之间的关联。病例报告及文献综述。
Association between DR3 and thrombocytopenia due to gold or tiopronin. Case reports and review of the literature.
作者信息
Ferraccioli G F, Cavalieri F, Mercadanti M, Salaffi F, Ambanelli U, Savi M
出版信息
Clin Exp Rheumatol. 1985 Oct-Dec;3(4):341-3.
PMID:3910323
Abstract
Two patients who developed thrombocytopenia while on Tiopronin and gold salts respectively were HLA typed. Their common haplotype was A25(10), B8, DR3. A survey of the literature showed that the association between DR3 and the sudden onset form of thrombocytopenia is striking. A genetic predisposition, besides other unknown factors, seems to play a crucial role.
摘要
分别在服用硫普罗宁和金盐期间出现血小板减少症的两名患者进行了HLA分型。他们的共同单倍型是A25(10)、B8、DR3。一项文献调查显示，DR3与血小板减少症的突发形式之间的关联很显著。除其他未知因素外，遗传易感性似乎起着关键作用。
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