Department of Mathematics, Jamoum University College, Umm Al-Qura University, 24320, Makkah, Saudi Arabia.
Department of Mathematics, University of the Punjab, Lahore, 54590, Pakistan.
Sci Rep. 2024 Aug 5;14(1):18079. doi: 10.1038/s41598-024-68600-7.
This study aims to formulate a mathematical framework to examine how the Lassa virus spreads in humans of opposite genders. The stability of the model is analyzed at an equilibrium point in the absence of the Lassa fever. The model's effectiveness is evaluated using real-life data, and all the parameters needed to determine the basic reproduction number are estimated. Sensitivity analysis is performed to pinpoint the crucial parameters significantly influencing the spread of the infection. The interaction between threshold parameters and the basic reproduction number is simulated. Control theory is employed to devise and evaluate strategies, such as awareness campaigns, advocating condom usage, and deploying rodenticides to reduce the possibility of virus transmission efficiently.
本研究旨在构建一个数学框架，以研究拉沙病毒在不同性别的人类之间的传播方式。在没有拉沙热的情况下，在平衡点分析模型的稳定性。使用实际数据评估模型的有效性，并估计确定基本繁殖数所需的所有参数。进行敏感性分析以确定对感染传播有重大影响的关键参数。模拟阈值参数与基本繁殖数之间的相互作用。利用控制理论设计和评估策略，例如宣传活动、提倡使用避孕套和使用灭鼠剂，以有效地降低病毒传播的可能性。
