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免疫细胞和免疫相关基因在甲状腺乳头状癌肿瘤微环境中的作用及其在免疫治疗中的意义。

The role of immune cells and immune related genes in the tumor microenvironment of papillary thyroid cancer and their significance for immunotherapy.

机构信息

Department of Pathology, Chongqing Changshou District Maternal and Child Health Hospital, Chongqing, China.

Department of Pathology, Jiaxing University Affiliated Women and Children Hospital (Jiaxing Maternity and Child Health Care Hospital), Jiaxing University, Jiaxing, China.

出版信息

Sci Rep. 2024 Aug 5;14(1):18125. doi: 10.1038/s41598-024-69187-9.

DOI:10.1038/s41598-024-69187-9
PMID:39103463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300445/
Abstract

Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer (THCA) and shows a better prognosis than other types. However, further research is needed to determine the risk of PTC. We herein used the CIBERSORT algorithm to analyze the gene-expression profile obtained from TCGA, estimated the infiltration ratio of 22 immune cell types in tumor tissues and normal tissues, analyzed the differential expression of immune-related genes, and identified immune cells and immune-related genes related to clinical progress and prognosis. We uncovered 12 immune cell types and nine immune-related genes that were closely correlated with TNM staging, and two immune cell types (activated NK cells and γδT cells) and one immune-related gene (CD40LG) that were associated with prognosis. After evaluation, four immune cell types could be used to determine low-risk PTC, with six immune cell types and six immune-related genes closely associated with high-risk PTC. The type and quantity of infiltrating immune cells in the microenvironment of PTC, as well as immune-related genes, appear to be closely related to tumor progression and can therefore be used as important indicators for the evaluation of patient prognosis. We posit that the study of immune cells and immune-related genes in the tumor microenvironment will facilitate the determination of low-risk PTC more accurately, and that this will greatly promote the development of high-risk PTC immunotherapy.

摘要

甲状腺乳头状癌（PTC）是甲状腺癌（THCA）最常见的病理类型，其预后优于其他类型。然而，需要进一步研究来确定 PTC 的风险。本研究使用 CIBERSORT 算法分析了来自 TCGA 的基因表达谱，估计了肿瘤组织和正常组织中 22 种免疫细胞类型的浸润比例，分析了免疫相关基因的差异表达，并鉴定了与临床进展和预后相关的免疫细胞和免疫相关基因。我们发现了 12 种免疫细胞类型和 9 个与 TNM 分期密切相关的免疫相关基因，以及两种免疫细胞类型（活化的 NK 细胞和γδT 细胞）和一个与预后相关的免疫相关基因（CD40LG）。经过评估，四种免疫细胞类型可用于确定低危 PTC，六种免疫细胞类型和六种免疫相关基因与高危 PTC 密切相关。PTC 微环境中浸润免疫细胞的类型和数量以及免疫相关基因似乎与肿瘤进展密切相关，因此可以作为评估患者预后的重要指标。我们假设研究肿瘤微环境中的免疫细胞和免疫相关基因将有助于更准确地确定低危 PTC，这将极大地促进高危 PTC 免疫治疗的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/520aedb87e7f/41598_2024_69187_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/45f5371aa7ed/41598_2024_69187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/98337caf3f38/41598_2024_69187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/d60dc9144723/41598_2024_69187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/305fb1dd4ba2/41598_2024_69187_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/e92d29c7cee3/41598_2024_69187_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/520aedb87e7f/41598_2024_69187_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/45f5371aa7ed/41598_2024_69187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/98337caf3f38/41598_2024_69187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/d60dc9144723/41598_2024_69187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/305fb1dd4ba2/41598_2024_69187_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/e92d29c7cee3/41598_2024_69187_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0b/11300445/520aedb87e7f/41598_2024_69187_Fig6_HTML.jpg

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The role of immune cells and immune related genes in the tumor microenvironment of papillary thyroid cancer and their significance for immunotherapy.

Sci Rep. 2024-8-5

[2]
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[3]
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[4]
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[6]
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[7]
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[8]
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引用本文的文献

[1]
Association Between Triglyceride-Glucose Index and Malignant Risk in Thyroid Nodules: A Cross-Sectional Analysis.

J Inflamm Res. 2025-8-19

[2]
Non-contrast computed tomography radiomics model to predict benign and malignant thyroid nodules with lobe segmentation: A dual-center study.

World J Radiol. 2025-6-28

[3]
Application and recent advances in conventional biomarkers for the prognosis of papillary thyroid carcinoma.

Front Oncol. 2025-5-21

[4]
Systems biology approach delineates critical pathways associated with papillary thyroid cancer: a multi-omics data analysis.

Thyroid Res. 2025-4-11

[5]
The Application of microRNAs in Papillary Thyroid Cancer: A Bibliometric and Visualized Analysis.

Int J Gen Med. 2024-10-15

[6]
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance.

Cell Biol Toxicol. 2024-10-10

本文引用的文献

[1]
Oleanolic acid inhibits the tumor progression by regulating through the cytokine-cytokine receptor interaction pathway in 4T1-induced mice breast cancer model.

Heliyon. 2024-2-28

[2]
Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer.

Oral Oncol. 2024-3

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The Unexpected Benefit of TCR Cross-Reactivity in Cancer Immunotherapy.

Cancer Res. 2023-10-2

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Nucleic Acids Res. 2023-1-6

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Int Immunopharmacol. 2022-6

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Cancers (Basel). 2021-4-18

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Cells. 2020-9-14

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