NeuroTRACT International Association, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Brain Imaging Behav. 2024 Oct;18(5):1100-1120. doi: 10.1007/s11682-024-00904-8. Epub 2024 Aug 6.
Recent studies have suggested that the hippocampus (HC) is involved in cognitive and behavioral functions beyond memory. We aimed to investigate how the volume of each subfield of the HC is associated with distinct patterns of coping strategies, emotion regulation, and impulsivity in a healthy population.
We studied a total of 218 healthy subjects using the Leipzig mind-brain-body dataset. Participants were assessed for coping strategies, emotion regulation, and impulsivity using the Cognitive Emotion Regulation Questionnaire (CERQ), Coping Orientations to Problems Experienced (COPE), Impulsive Behavior Scale (UPPS), and Behavioral Activation and Inhibition System (BAS/BIS). The associations between HC subfield volumes including CA1, CA2/3, CA4/DG, SR-SL-SM, and subiculum, and behavioral scores were examined using multiple linear regression models adjusted for possible confounders, including age, sex, years of education, handedness, total intracranial volume (ICV), and HC volume.
The use of emotional support, venting, and positive reframing coping strategies were significantly and positively correlated with total, total right, and total left HC volumes. Venting was significantly associated with CA1 after adjusting for age, sex, handedness, and education (P=0.001, B = 0.265, P-FDR = 0.005). No significant association was observed between CERQ subscales and HC subfield volumes after controlling for confounders and multiple analyses. However, sensation-seeking subscale of the UPPS-P was positively correlated with total and right CA2-CA3 volumes after adjustments for age, sex, handedness, ICV, and HC volumes (P=0.002, B = 0.266, P-FDR = 0.035). BAS and BIS subscales did not show significant relationship with HC subfield volumes.
Patterns of HC subfields volumes are associated with coping strategies, impulsivity, and emotion regulation. In particular, using emotional support, positive reframing, venting, and sensation seeking are significantly associated with certain HC subfield volumes. These findings suggest that the hippocampus may play a crucial role in modulating emotional responses and behavioral adaptations, offering potential targets for therapeutic interventions.
最近的研究表明，海马体（HC）除了与记忆有关外，还参与认知和行为功能。我们旨在研究健康人群中 HC 各亚区的体积如何与不同的应对策略、情绪调节和冲动模式相关。
我们使用莱比锡脑-心-身数据集对总共 218 名健康受试者进行了研究。使用认知情绪调节问卷（CERQ）、应对体验问卷（COPE）、冲动行为量表（UPPS）和行为激活和抑制系统（BAS/BIS）评估了参与者的应对策略、情绪调节和冲动。在调整了可能的混杂因素（包括年龄、性别、受教育年限、手性、总颅内体积（ICV）和 HC 体积）后，使用多元线性回归模型来检验 HC 亚区体积（包括 CA1、CA2/3、CA4/DG、SR-SL-SM 和 subiculum）与行为评分之间的关联。
使用情感支持、宣泄和积极重新解释应对策略与总 HC 体积、总右 HC 体积和总左 HC 体积呈显著正相关。宣泄在调整年龄、性别、手性和教育后与 CA1 显著相关（P=0.001，B=0.265，P-FDR=0.005）。在控制混杂因素和多次分析后，CERQ 分量表与 HC 亚区体积之间未见显著相关性。然而，在调整年龄、性别、手性、ICV 和 HC 体积后，UPPS-P 的感觉寻求分量表与总 HC 体积和右 CA2-CA3 体积呈正相关（P=0.002，B=0.266，P-FDR=0.035）。BAS 和 BIS 分量表与 HC 亚区体积无显著相关性。
HC 亚区体积模式与应对策略、冲动和情绪调节有关。特别是，使用情感支持、积极重新解释、宣泄和感觉寻求与某些 HC 亚区体积显著相关。这些发现表明，海马体可能在调节情绪反应和行为适应方面发挥关键作用，为治疗干预提供了潜在靶点。
