Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, CHINA.
Med Sci Sports Exerc. 2023 Jul 1;55(7):1208-1217. doi: 10.1249/MSS.0000000000003144. Epub 2023 Feb 28.
Numerous studies have implicated the involvement of structure and function of the hippocampus in physical exercise, and the larger hippocampal volume is one of the relevant benefits reported in exercise. It remains to be determined how the different subfields of hippocampus respond to physical exercise.
A 3D T1-weighted magnetic resonance imaging was acquired in 73 amateur marathon runners (AMR) and 52 healthy controls (HC) matched with age, sex, and education. The Montreal Cognitive Assessment, the Pittsburgh Sleep Quality Index (PSQI), and the Fatigue Severity Scale were assessed in all participants. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the two groups and ascertained correlation between the significant subfield metrics and the significant behavioral measure in AMR group.
The AMR had significantly better sleep than HC, manifested as with lower score of PSQI. Sleep duration in AMR and HC was not significantly different from each other. In the AMR group, the left and right hippocampus, cornu ammonis 1 (CA1), CA4, granule cell and molecular layers of the dentate gyrus, molecular layer, left CA2-3, and left hippocampal-amygdaloid transition area volumes were significantly larger compared with those in the HC group. In AMR group, the correlations between the PSQI and the hippocampal subfield volumes were not significant. No correlations were found between hippocampal subfield volumes and sleep duration in AMR group.
We reported larger volumes of specific hippocampal subfields in AMR, which may provide a hippocampal volumetric reserve that protects against age-related hippocampal deterioration. These findings should be further investigated in longitudinal studies.
大量研究表明，海马体的结构和功能与体育锻炼有关，而较大的海马体体积是运动带来的相关益处之一。目前仍不清楚海马体的不同亚区如何对体育锻炼产生反应。
在 73 名业余马拉松运动员（AMR）和 52 名年龄、性别和教育程度相匹配的健康对照者（HC）中采集了 3D T1 加权磁共振成像（MRI）。所有参与者均接受蒙特利尔认知评估、匹兹堡睡眠质量指数（PSQI）和疲劳严重程度量表评估。我们使用 FreeSurfer 6.0 获得海马亚区体积。我们比较了两组之间海马亚区的体积，并确定了 AMR 组中显著亚区指标与显著行为测量之间的相关性。
AMR 的睡眠质量明显优于 HC，表现为 PSQI 评分较低。AMR 和 HC 的睡眠时间无明显差异。在 AMR 组中，左侧和右侧海马体、角回 1（CA1）、CA4、齿状回颗粒细胞和分子层、分子层、左侧 CA2-3 和左侧海马杏仁核过渡区的体积明显大于 HC 组。在 AMR 组中，PSQI 与海马亚区体积之间的相关性不显著。在 AMR 组中，海马亚区体积与睡眠时间之间未发现相关性。
我们报道了 AMR 中海马体特定亚区的体积增大，这可能为抵抗与年龄相关的海马体恶化提供了海马体容积储备。这些发现应在纵向研究中进一步探讨。
