Li Hongjiang, Pan Chunxiang, Li Xinhan, He Zhenxiu, Sun Xueyan, Xu Jianbin, Wang Kaimin, Fan Baomin
Yunnan Key Laboratory of Chiral Functional Substance Research and Application, Yunnan Minzu University, Kunming, Yunnan 650504, China.
J Org Chem. 2024 Aug 16;89(16):11537-11541. doi: 10.1021/acs.joc.4c01233. Epub 2024 Aug 5.
We have developed a photocatalyst-free reaction system that uses Hantzsch esters as photoreducing agents to promote the coupling of carbonyl compounds to 1,2-diols. The system fully utilizes the single electron transfer and proton donor roles of Hantzsch esters. The system shows a wide range of substrate application. Aromatic ketones, aliphatic ketones, and aldehydes can be applied to the catalytic system. Both self-coupling and cross-coupling can achieve ideal results.
我们开发了一种无光催化剂的反应体系，该体系使用汉斯酯作为光还原剂来促进羰基化合物与1,2 -二醇的偶联反应。该体系充分利用了汉斯酯的单电子转移和质子供体作用。该体系具有广泛的底物适用性。芳香酮、脂肪族酮和醛均可应用于该催化体系。自偶联和交叉偶联均可取得理想结果。
