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Phosphodiesterase 9 localization in cytoplasm and nucleus: the gateway to selective targeting in neuroprotection?

作者信息

Ribaudo Giovanni, Giannangeli Matteo, Anyanwu Margrate, Gianoncelli Alessandra

机构信息

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

出版信息

Neural Regen Res. 2025 Jun 1;20(6):1701-1702. doi: 10.4103/NRR.NRR-D-24-00373. Epub 2024 Jul 10.

DOI:10.4103/NRR.NRR-D-24-00373
PMID:39104101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688560/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0578/11688560/419f43807417/NRR-20-1701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0578/11688560/419f43807417/NRR-20-1701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0578/11688560/419f43807417/NRR-20-1701-g001.jpg

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本文引用的文献

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Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model.虚拟筛选——在海人酸毒性体外模型中发现具有神经保护作用的磷酸二酯酶 9 抑制剂。
ACS Chem Neurosci. 2023 Oct 18;14(20):3826-3838. doi: 10.1021/acschemneuro.3c00431. Epub 2023 Sep 19.
2
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory.依赖衔接蛋白的磷酸二酯酶 4D 核输出促进 G 蛋白偶联受体诱导的学习记忆所必需的核 cAMP 信号转导。
Sci Signal. 2023 Mar 28;16(778):eade3380. doi: 10.1126/scisignal.ade3380.
3
Virtual screening and in vitro experiments highlight cannabidiol as a drug-like phosphodiesterase 9 inhibitor.
虚拟筛选和体外实验凸显大麻二酚具有类药物磷酸二酯酶 9 抑制剂的特性。
Eur J Neurosci. 2023 Jun;57(12):1954-1965. doi: 10.1111/ejn.15869. Epub 2022 Nov 25.
4
The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson's Disease by Inhibiting the NF-κB/NLRP3 Pathway.XPO1抑制剂KPT-8602通过抑制NF-κB/NLRP3通路改善帕金森病。
Front Pharmacol. 2022 Jun 1;13:847605. doi: 10.3389/fphar.2022.847605. eCollection 2022.
5
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Alzheimer Dis Assoc Disord. 2022;36(3):200-207. doi: 10.1097/WAD.0000000000000515. Epub 2022 Jun 9.
6
A single-cell type transcriptomics map of human tissues.人类组织单细胞转录组图谱。
Sci Adv. 2021 Jul 28;7(31). doi: 10.1126/sciadv.abh2169. Print 2021 Jul.
7
Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.鉴定新的 PDE9A 同工型及其在大脑中的表达和亚细胞区室分布如何随生命周期而变化。
Neurobiol Aging. 2018 May;65:217-234. doi: 10.1016/j.neurobiolaging.2018.01.019. Epub 2018 Feb 5.
8
Epac Function and cAMP Scaffolds in the Heart and Lung.心脏和肺部中的Epac功能与cAMP支架
J Cardiovasc Dev Dis. 2018 Feb 3;5(1):9. doi: 10.3390/jcdd5010009.
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Oral Dis. 2015 Jan;21(1):e25-50. doi: 10.1111/odi.12275. Epub 2014 Sep 12.