Wezeman Jackson, Keely Addison, Ladiges Warren
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
Aging Pathobiol Ther. 2023;5(4):151-153. doi: 10.31491/apt.2023.12.127. Epub 2023 Dec 26.
There has been little progress in reducing the incidence and mortality of Alzheimer's disease (AD). Prevention of onset, more accurate diagnostic tools, and prediction of health outcomes have all been identified as critical issues, but more and better basic research approaches are needed. The single greatest risk factor associated with AD is aging. It follows that if aging can be delayed, there should be an equivalent delay or even prevention of the onset of AD neuropathology. Therefore, targeting multiple pathways of aging would be a powerful way to enhance resilience to aging and slow or prevent the onset of AD neuropathology and dementia in a personalized manner. More effective and predictive animal models, such as the aging pet cat that spontaneously develops neuropathology similar to human AD patients, are necessary to help validate noninvasive and inexpensive biomarkers for identifying individuals at risk. Resilience to aging and its ability to delay or prevent the onset of age-related diseases should be the focus for preventing brain aging and enhancing resistance to AD.
在降低阿尔茨海默病（AD）的发病率和死亡率方面进展甚微。预防发病、更精确的诊断工具以及健康结果预测都已被确定为关键问题，但仍需要更多更好的基础研究方法。与AD相关的最大单一风险因素是衰老。因此，如果衰老能够被延缓，那么AD神经病理学的发病也应该会相应延迟甚至预防。所以，针对衰老的多种途径将是一种强有力的方式，以个性化的方式增强对衰老的抵御能力，并减缓或预防AD神经病理学和痴呆症的发病。更有效且具有预测性的动物模型，比如会自发出现类似于人类AD患者神经病理学特征的衰老宠物猫，对于帮助验证用于识别高危个体的非侵入性且廉价的生物标志物是必要的。对衰老的抵御能力及其延缓或预防与年龄相关疾病发病的能力，应该成为预防脑衰老和增强对AD抵抗力的重点。
