Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Front Immunol. 2024 Jul 22;15:1425443. doi: 10.3389/fimmu.2024.1425443. eCollection 2024.
T cells, as a major lymphocyte population involved in the adaptive immune response, play an important immunomodulatory role in the early stages of autoimmune diseases. Autophagy is a cellular catabolism mediated by lysosomes. Autophagy maintains cell homeostasis by recycling degraded cytoplasmic components and damaged organelles. Autophagy has a protective effect on cells and plays an important role in regulating T cell development, activation, proliferation and differentiation. Autophagy mediates the participation of T cells in the acquired immune response and plays a key role in antigen processing as well as in the maintenance of T cell homeostasis. In autoimmune diseases, dysregulated autophagy of T cells largely influences the pathological changes. Therefore, it is of great significance to study how T cells play a role in the immune mechanism of autoimmune diseases through autophagy pathway to guide the clinical treatment of diseases.
T 细胞作为参与适应性免疫应答的主要淋巴细胞群，在自身免疫性疾病的早期阶段发挥重要的免疫调节作用。自噬是溶酶体介导的细胞分解代谢过程。自噬通过回收降解的细胞质成分和受损的细胞器来维持细胞内环境的稳定。自噬对细胞具有保护作用，并在调节 T 细胞的发育、激活、增殖和分化中发挥重要作用。自噬介导 T 细胞参与获得性免疫应答，并在抗原加工以及 T 细胞内环境稳定的维持中发挥关键作用。在自身免疫性疾病中，T 细胞的自噬失调在很大程度上影响了病理变化。因此，研究 T 细胞如何通过自噬途径在自身免疫性疾病的免疫机制中发挥作用，以指导疾病的临床治疗具有重要意义。
